Evidence map›Paper›PMID 39767180›Full record

ReviewDiagnostics (Basel, Switzerland)2024

COPA Syndrome-From Pathogenesis to Treatment.

Vlad Padureanu, Mircea-Cătălin Forțofoiu, Ionut Donoiu, Eugen-Nicolae Tieranu, Catalin Dumitrascu, Rodica Padureanu, Anca Emanuela Mușetescu, Cristina Alexandru, Carmen Catalina Iorgus, Florin Bobirca and 2 more

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vlad PadureanuDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0001-7398-5689
Mircea-Cătălin ForțofoiuDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0002-3341-1442
Ionut DonoiuDepartment of Cardiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0001-6338-2657
Eugen-Nicolae TieranuDepartment of Cardiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Catalin DumitrascuDepartment of Internal Medicine and Rheumatology, "Dr. Ion Cantacuzino" Clinical Hospital, 011437 Bucharest, Romania.
Rodica PadureanuDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0002-3095-736X
Anca Emanuela MușetescuDepartment of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Cristina AlexandruDepartment of Internal Medicine and Rheumatology, "Dr. Ion Cantacuzino" Clinical Hospital, 011437 Bucharest, Romania.ORCID 0000-0001-7053-7530
Carmen Catalina IorgusDepartment of Internal Medicine and Rheumatology, "Dr. Ion Cantacuzino" Clinical Hospital, 011437 Bucharest, Romania.
Florin BobircaDepartment of General Surgery, "Carol Davila" University of Medicine and Pharmacy, "Dr. Ion Cantacuzino" Clinical Hospital, 030167 Bucharest, Romania.ORCID 0000-0002-8944-3857
Ana DascaluDepartment of Ophthalmology, Emergency University Hospital Bucharest, 050098 Bucharest, Romania.ORCID 0000-0002-7474-2395
Anca BobircaDepartment of Internal Medicine and Rheumatology, "Dr. Ion Cantacuzino" Clinical Hospital, 011437 Bucharest, Romania.ORCID 0000-0002-6662-7354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coatomer subunit α (COPA) syndrome is a mendelian autosomal dominant immune dysregulation disease characterized by early onset lung disease in the form of diffuse alveolar hemorrhaging or interstitial lung disease, frequently associated with arthritis, glomerulonephritis, and high titer autoantibodies usually mimicking other autoimmune diseases. While immunosuppressive medication has been effective in controlling arthritis, data on long-term lung disease control remains scarce, which poses a real challenge as the progression of lung disease is the main cause of poor life expectancy in COPA patients. Nevertheless, JAK inhibitor therapy seems to be the most promising therapeutic choice now.

Indexed as

arthritisCOPA syndromediffuse alveolar hemorrhagingimmune dysregulationinterstitial lung disease

Identifiers

PMID39767180
PMCPMC11674574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.