Genetic Association Study of Acetylcholinesterase (

Dong Qu, Peter Schürmann, Thomas Rothämel, Thilo Dörk, Michael Klintschar

Abstract read

In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Gene replacement therapy for Piga GPI-anchor deficiency in the developing nervous system.bioRxiv : the preprint server for biology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dong QuInstitute of Legal Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0002-5177-0174

Peter SchürmannGynaecology Research Unit, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Thomas RothämelInstitute of Legal Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Thilo DörkGynaecology Research Unit, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.ORCID 0000-0002-9458-0282

Michael KlintscharInstitute of Legal Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSudden infant death syndrome (SIDS) is the leading cause of death among infants aged between one month and one year. Altered enzyme activities or expression of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) have been observed in SIDS patients that might lead to disturbed autonomic function and, together with other risk factors, might trigger SIDS. To explore the contribution of AChE and BChE from a genomic viewpoint, we sought to investigate the association between SIDS and selected single nucleotide polymorphisms (SNPs) in the

methodsIn this case-control study, 13 potentially regulatory SNPs were selected from

resultsNo significant overall associations were observed between SIDS and

conclusionsThe selected variants in

Indexed as

AcetylcholinesteraseButyrylcholinesterasePolymorphism, Single NucleotideSudden Infant DeathCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGPI-Linked ProteinsHaplotypesHumansInfantInfant, NewbornMaleAcetylcholinesteraseACHE protein, humanBCHE protein, humanButyrylcholinesteraseGPI-Linked ProteinsACHEBCHEgenetic associationpolymorphismssudden infant death syndrome (SIDS)

Identifiers

PMID39766923

DOI10.3390/genes15121656

PMCPMC11727802

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.