Evidence map›Paper›PMID 39766918›Full record

ArticleGenes2024

Complete Genome Assembly of

Anastasia Stepanyshyn, Christian Rückert-Reed, Tobias Busche, Bohdan Yaruta, Andres Andreo-Vidal, Flavia Marinelli, Jörn Kalinowski, Oleksandr Yushchuk

Abstract read
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anastasia StepanyshynDepartment of Genetics and Biotechnology, Ivan Franko National University of Lviv, 79005 Lviv, Ukraine.ORCID 0009-0003-5687-1446
Christian Rückert-ReedTechnology Platform Genomics, CeBiTec, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.ORCID 0000-0002-9722-4435
Tobias BuscheTechnology Platform Genomics, CeBiTec, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.ORCID 0000-0001-9211-8927
Bohdan YarutaDepartment of Genetics and Biotechnology, Ivan Franko National University of Lviv, 79005 Lviv, Ukraine.
Andres Andreo-VidalDepartment of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-5446-7544
Flavia MarinelliDepartment of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-9195-6777
Jörn KalinowskiTechnology Platform Genomics, CeBiTec, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.ORCID 0000-0002-9052-1998
Oleksandr YushchukDepartment of Genetics and Biotechnology, Ivan Franko National University of Lviv, 79005 Lviv, Ukraine.ORCID 0000-0003-3296-8297

Funding

Alexander von Humboldt Foundation Research Fellowship for PostdocsEURIZON project Funded by the European Union under grant agreement No.871072
6 · The paper itself

Abstract

backgroundGlycopeptide antibiotics (GPAs) are a very successful class of clinically relevant antibacterials, used to treat severe infections caused by Gram-positive pathogens, e.g., multidrug resistant and methicillin-resistant staphylococci. The biosynthesis of GPAs is coded within large biosynthetic gene clusters (BGCs). In recent years, modern DNA sequencing technologies have allowed the identification and characterization of multiple novel GPA BGCs, leading to the discovery of novel compounds. Our previous research anticipated that the genome of

objectivesTo address this gap, in the current work we aimed to produce a complete genome assembly of

methodsBioinformatic and microbiological methods were utilized in this research.

resultsWe de novo sequenced and completely assembled the genome of

conclusionsOur results indicate

Indexed as

AmycolatopsisGenome, BacterialGlycopeptidesMultigene FamilyAnti-Bacterial AgentsBacterial ProteinsAnti-Bacterial AgentsBacterial ProteinsGlycopeptidesactinomycetesbiosynthetic gene clustergenome sequencingglycopeptide antibioticsin silico analysis

Identifiers

PMID39766918
PMCPMC11727664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.