Evidence map›Paper›PMID 39766906›Full record

ArticleGenes2024

Relationship of Interleukin 6 with Hepatic Steatosis and Liver Fibrosis in Rheumatoid Arthritis at a Rheumatology Care Center in Cartagena, Colombia.

Gloria Caterine Pérez-Mingan, Rita Magola Sierra-Merlano, Ismael Yepes, María Judith Palomino Vergara, Miguel Ortiz, Breiner Peña, Eder Cano-Pérez, Doris Gómez-Camargo

Abstract read
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gloria Caterine Pérez-MinganDepartamento de Medicina Interna, Facultad de Medicina, Universidad de Cartagena, Cartagena 130001, Colombia.ORCID 0000-0002-7243-4065
Rita Magola Sierra-MerlanoDepartamento de Medicina Interna, Facultad de Medicina, Universidad de Cartagena, Cartagena 130001, Colombia.
Ismael YepesDepartamento de Medicina Interna, Facultad de Medicina, Universidad de Cartagena, Cartagena 130001, Colombia.
María Judith Palomino VergaraPrograma de Medicina, Facultad de Medicina, Universidad de Cartagena, Cartagena 130001, Colombia.ORCID 0000-0002-2443-6891
Miguel OrtizPrograma de Medicina, Facultad de Ciencias de la Salud, Universidad del Sinú, Cartagena 130001, Colombia.
Breiner PeñaPrograma de Medicina, Facultad de Ciencias de la Salud, Universidad del Magdalena, Santa Marta 470001, Colombia.
Eder Cano-PérezGrupo de Investigación UNIMOL, Facultad de Medicina, Universidad de Cartagena, Cartagena 130001, Colombia.
Doris Gómez-CamargoGrupo de Investigación UNIMOL, Facultad de Medicina, Universidad de Cartagena, Cartagena 130001, Colombia.

Funding

UNIMOL None
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study aimed to investigate the association of IL-6 with steatotic liver disease (SLD) and liver fibrosis (LF) in rheumatoid arthritis (RA) patients at a rheumatology center in Cartagena de Indias, Colombia.

methodsThis was a cross-sectional study that included RA and non-RA cases. The level of cellular expression of interleukin 6 (IL-6) was evaluated by flow cytometry in peripheral blood leukocytes, and the presence of SLD and LF was detected by elastosonography. The main outcome was to establish the association between the levels of cellular expression of IL-6 and the development of SLD and LF.

resultsThis study included 47 cases of RA and 34 cases on-RA, with a mean age of 54 and 55 years, respectively. The frequency of SLD was 55.3% in RA and 38.2% in non-RA. The frequency of LF was 12.8% in RA and 14.7% in non-RA, with no statistical difference. The levels of cellular expression of IL-6 were significantly higher in RA compared to non-RA. Cellular expression of IL-6 was associated with the presence of SLD (54% vs. 30.3%;

conclusionsIL-6 levels were related to SLD in the evaluated sample, and RA was not a risk factor for SLD or LF. The prognostic role of IL-6 for SLD in patients with RA requires further studies.

Indexed as

Arthritis, RheumatoidInterleukin-6Liver CirrhosisAdultAgedColombiaCross-Sectional StudiesFatty LiverFemaleHumansMaleMiddle AgedIL6 protein, humanInterleukin-6cytokinesinterleukin 6liver fibrosisrheumatoid arthritis

Identifiers

PMID39766906
PMCPMC11675702

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.