Evidence map›Paper›PMID 39766798›Full record

ArticleGenes2024

Deeply Saddening Life Events Play a Carcinogenic Role by Inducing Mutations in

Ahmet Kutluhan, Osman Z Topak, Hakan Akca, Elvan Tokgun, Osman I Ozdel, Sevda Yilmaz, Ugur Sungurtekin, Ergun Erdem, Arzu Yaren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmet KutluhanDepartment of Otolaryngology, Head and Neck Surgery, Pamukkale University School of Medicine, Denizli 20070, Turkey.
Osman Z TopakDepartment of Psychiarty, Pamukkale University School of Medicine, Denizli 20070, Turkey.
Hakan AkcaDepartment of Medical Genetic, Pamukkale University School of Medicine, Denizli 20070, Turkey.
Elvan TokgunDepartment of Medical Genetic, Pamukkale University School of Medicine, Denizli 20070, Turkey.
Osman I OzdelDepartment of Psychiarty, Pamukkale University School of Medicine, Denizli 20070, Turkey.
Sevda YilmazDepartment of Surgery, Pamukkale University School of Medicine, Denizli 20070, Turkey.
Ugur SungurtekinDepartment of Surgery, Pamukkale University School of Medicine, Denizli 20070, Turkey.
Ergun ErdemDepartment of Surgery, Pamukkale University School of Medicine, Denizli 20070, Turkey.
Arzu YarenDepartment of Medical Oncology, Pamukkale University School of Medicine, Denizli 20070, Turkey.

Funding

Pamukkale University BAP 2022KRM002 and 2021KRM001
6 · The paper itself

Abstract

BACKGROUND/

objectivesIn the past few decades, many studies have been conducted to find out that psychological stress and cancer are closely linked. Moreover, it was reported that stress can induce mutations in gene level. Therefore, in this study we want to examine a relationship between stressful life events, gene mutation and cancer.

methodsStressful Life Experiences Screening (SLES), Hospital Anxiety and Depression Scale (HADS) and the Coping with Stress Style Scale (CSS) were applied to the participants to examine relationship between stress and cancer.

resultsNGS results showed higher level of mutations accumulated on

conclusionsOur results indicate that Stressful Life Experiences may induce cancer development by increased somatic mutations in

Indexed as

Arachidonate 12-LipoxygenaseMutationNeoplasmsStress, PsychologicalTacrolimus Binding ProteinsAdultAnimalsCarcinogenesisCell Line, TumorFemaleHumansMaleMiceMiddle AgedTacrolimus Binding Protein 5ALOX12 protein, humanArachidonate 12-LipoxygenaseTacrolimus Binding Protein 5Tacrolimus Binding ProteinsALOX12cancerFKBP5mutationspsychological stressStressful Life Experiences

Identifiers

PMID39766798
PMCPMC11675945

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.