Evidence map›Paper›PMID 39766612›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Goondicones A-H: Spiro-Isoindolinone Heartworm Anthelmintics from an Australian Pasture-Soil-Derived

Jianying Han, David F Bruhn, Cynthia T Childs, Yovany Moreno, Angela A Salim, Taizong Wu, Robert J Capon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianying HanInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0003-4402-6598
David F BruhnBoehringer Ingelheim Animal Health, USA Inc., 1730 Olympic Drive, Athens, GA 30601, USA.
Cynthia T ChildsBoehringer Ingelheim Animal Health, USA Inc., 1730 Olympic Drive, Athens, GA 30601, USA.
Yovany MorenoBoehringer Ingelheim Animal Health, USA Inc., 1730 Olympic Drive, Athens, GA 30601, USA.
Angela A SalimInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-8177-5689
Taizong WuKey Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
Robert J CaponInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-8341-7754

Funding

Australian Research Council LE210100148Australian Research Council LP190100083
6 · The paper itself

Abstract

BACKGROUND/

objectivesThere is an urgent need for new and improved anthelmintics that are not constrained by existing resistance pathways and that can safeguard the health and welfare of animals.

methodsAn integrated platform of chemical, bioassay, and cultivation profiling applied to a library of microbes isolated from Australian livestock pasture soil was used to detect and guide the production, isolation, characterization, identification, and evaluation of new natural products with anthelmintic properties.

resultsA global natural products social (GNPS) molecular network analysis of 110 Australian pasture-soil-derived microbial extracts prioritized for antiparasitic activity identified unique molecular families in the extract of

conclusionsWhile goondicones

Indexed as

anthelminticcitizen scienceDirofilaria immitismicrobial natural productSoils for Sciencespiro-isoindolinoneStreptomyces

Identifiers

PMID39766612
PMCPMC11727212

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.