Evidence map›Paper›PMID 39766597›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Fusion Partner Facilitates Expression of Cell-Penetrating Peptide L2 in

Xuan Li, Na Yang, Yuxin Fang, Ruoyu Mao, Ya Hao, Da Teng, Na Dong, Anshan Shan, Jianhua Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Systematic optimization ofEngineering microbiology · 2026
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuan LiGene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie St., Haidian District, Beijing 100081, China.
Na YangGene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie St., Haidian District, Beijing 100081, China.
Yuxin FangLaboratory of Molecular Nutrition and Immunity, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150038, China.
Ruoyu MaoGene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie St., Haidian District, Beijing 100081, China.ORCID 0000-0002-3684-9933
Ya HaoGene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie St., Haidian District, Beijing 100081, China.
Da TengGene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie St., Haidian District, Beijing 100081, China.
Na DongLaboratory of Molecular Nutrition and Immunity, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150038, China.
Anshan ShanLaboratory of Molecular Nutrition and Immunity, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150038, China.
Jianhua WangGene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie St., Haidian District, Beijing 100081, China.ORCID 0000-0002-4048-6055

Funding

National Key Research and Development Plan 2022YFC2105000-03National Key Research and Development Plan 2023YFD1301102National Natural Science Foundation of China 31872393National Natural Science Foundation of China U21A20252The Innovation Program of Agricultural Science and Technology (ASTIP) in Chinese Academy of Agricultural Sciences (CAAS) CAAS-ASTIP-2017-FRI-02The key projects of Innovation Program of Agricultural Science and Technology (ASTIP) in Chinese Academy of Agricultural Sciences (CAAS) CAAS-ZDXT 2018008The key projects of Innovation Program of Agricultural Science and Technology (ASTIP) in Chinese Academy of Agricultural Sciences (CAAS) No. CAAS-ZDRW202111
6 · The paper itself

Abstract

backgroundL2 is formed by combining the pheromone of

methodsThis study was devoted to the heterologous expression of the cell-penetrating peptide L2 in

resultsThe results showed that SUMO-L2 expression in the 5 L fermenter reached 629 mg/L. The antibacterial activity of recombinant L2 was examined; the minimum inhibitory concentration (MICs) and minimum bactericidal concentration (MBCs) of purified L2 were 4-8 μg/mL and 8-16 μg/mL against

conclusionsThe findings suggest that SUMO is a suitable fusion tag to express cell-penetrating peptide L2.

Indexed as

cell-penetrating peptide L2fusion expressionPichia pastorissmall fusion tagssmall ubiquitin-related modifier (SUMO)

Identifiers

PMID39766597
PMCPMC11672777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.