Evidence map›Paper›PMID 39766534›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Integrating Diagnostic Approaches in Infant Bacterial Meningitis Caused by a Non-K1

Gianluca Vrenna, Marilena Agosta, Valeria Fox, Martina Rossitto, Venere Cortazzo, Serena Raimondi, Barbara Lucignano, Manuela Onori, Livia Mancinelli, Maria Del Carmen Pereyra Boza and 8 more

Abstract readCase Reports
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gianluca VrennaMultimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-6906-9506
Marilena AgostaMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-6017-3232
Valeria FoxMultimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-4552-8461
Martina RossittoMultimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-5331-3973
Venere CortazzoMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-7129-9001
Serena RaimondiMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Barbara LucignanoMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Manuela OnoriMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Livia MancinelliMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Maria Del Carmen Pereyra BozaMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Vanessa FiniMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Annarita GranagliaMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Laura LancellaInfectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Francesca Ippolita Calo' CarducciInfectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-6087-8323
Costanza TripicianoInfectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-6712-2334
Alberto VillaniGeneral Pediatric and Infectious Disease Unit, Pediatric Emergency Medicine, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-9120-0424
Paola BernaschiMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Carlo Federico PernoMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

Funding

EU funding within the NextGenerationEU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project no. PE00000007, INF-ACT)Italian Ministry of Health with "Current Research funds" no grant number
6 · The paper itself

Abstract

backgroundInfant meningitis, particularly caused by

methodsAt Bambino Gesù Children's Hospital, molecular diagnostic tools, including the FilmArray Meningitis/Encephalitis and Blood Culture Identification panels, were employed.

resultsAlthough the Meningitis panel did not detect any pathogens due to the lack of the specific bacterial target, the off-label use of the Blood Culture Identification panel identified a non-K1

conclusionsThis case highlights the importance of integrating advanced molecular diagnostics, such as whole-genome sequencing, with traditional methods to improve pathogen detection, especially in cases of emerging resistant strains that are not covered by standard diagnostic panels. It also emphasizes the need for the continuous adaptation of diagnostic tools to include non-K1

Indexed as

FilmArrayinfant meningitisnon-K1 Escherichia coliwhole-genome sequencing

Identifiers

PMID39766534
PMCPMC11672694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.