Evidence map›Paper›PMID 39766486›Full record

ArticleBrain sciences2024

5-HT

Brianna L Minshall, Catherine F Wasylyshyn, Kate M Brand, Caroline M Bartoszek, Kennedy A Seipel, Madeline M Booms, Lucy C Chappell, Amanda N Reichert, Jacob R Dowell, Angeles L Buck and 3 more

Abstract read
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In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brianna L MinshallDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Catherine F WasylyshynDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.ORCID 0000-0001-5327-728X
Kate M BrandDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Caroline M BartoszekDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Kennedy A SeipelDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Madeline M BoomsDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Lucy C ChappellDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Amanda N ReichertDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Jacob R DowellDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Angeles L BuckDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Henry T BeckettDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.ORCID 0009-0009-9830-4187
Christopher A LowryDepartment of Integrative Physiology, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.ORCID 0000-0003-3920-5575
Jennifer J QuinnDepartment of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.

Funding

NIH HHS 1R21AA028602-01A1
6 · The paper itself

Abstract

BACKGROUND/

objectivesRodents provide a useful translational model of fear- and anxiety-related behaviors. Previously stressed animals exhibit physiological and behavioral stress responses that parallel those observed in anxious humans. Patients diagnosed with post-traumatic stress disorder (PTSD) present with a spectrum of debilitating anxiety symptoms that result from exposure to one or more traumatic events, with individuals exposed to early adverse experiences and women having increased vulnerability for diagnoses; however, the mechanisms of this increased vulnerability remain unknown. PTSD involves a complex network of highly interconnected brain regions, including the bed nucleus of the stria terminalis (BNST). Serotonin (5-HT) release into the BNST yields an increased expression of both fear and anxiety, specifically through 5-HT

methodsRats received 0 or 15 footshocks on postnatal day 17, an established model of acute ELS (aELS) that yields enhanced adult fear learning. In adulthood, rats received bilateral infusions of a vehicle, a 5-HT

resultsFemales demonstrated aELS-induced enhancement in contextual fear learning, while males did not. BNST infusions of RS-102221 reduced contextual fear conditioning, independent of aELS condition and sex. Infusions of MK-212 had no effect.

conclusionsTaken together, these data suggest that serotonergic signaling through 5-HT

Indexed as

bed nucleus of the stria terminalisearly-life stresspost-traumatic stress disorderSEFLserotoninstress-enhanced fear learning

Identifiers

PMID39766486
PMCPMC11674907

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.