The Impact of Dexamphetamine Treatment for Obesity on Executive Function: A Double-Blind Randomised Controlled Pilot Study.

Antoinette Poulton, Natalie Gauci, Hazer Khalifa, Emily J Hibbert, Alison S Poulton

Abstract read

In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Antoinette PoultonMelbourne School of Psychological Sciences, University of Melbourne, Parkville, VIC 3052, Australia.ORCID 0000-0001-9291-6128

Natalie GauciNepean Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2751, Australia.ORCID 0009-0001-0533-6350

Hazer KhalifaNepean Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2751, Australia.ORCID 0000-0001-6965-0712

Emily J HibbertNepean Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2751, Australia.ORCID 0000-0002-1151-2816

Alison S PoultonNepean Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2751, Australia.ORCID 0000-0002-5867-2403

Funding

National Health and Medical Research Council 2031836Nepean Hospital Department of Cardiology Trust Fund NA

6 · The paper itself

Abstract

backgroundAmphetamines increase dopamine levels in mid-brain regions which, in turn, impact top-down executive function. Repeated exposure is linked to substance use disorders. Nonetheless, amphetamines are used to manage attention-deficit/hyperactivity disorder (ADHD) and eating-related disorders. In ADHD, amphetamines upregulate a system characterised by low dopaminergic tone, assisting to improve executive function. A similar process might be at play with eating disorders; however, the effect of amphetamine treatment on executive function in this case has not been thoroughly considered.

methodsParticipants (

resultsThere was no effect of group (

conclusionsThere was no discernible impact of amphetamine treatment for obesity on executive function. Our results suggest some variation related to sample size and/or practice effects. Thus, while treatment appears unlikely to render individuals susceptible to substance use disorders, parallels with ADHD might be overstated.

Indexed as

attention-deficit/hyperactivity disorderdexamphetamineexecutive functionobesityresponse inhibitionsubstance use disorder

Identifiers

PMID39766473

DOI10.3390/brainsci14121274

PMCPMC11674214

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.