Evidence map›Paper›PMID 39766462›Full record

ArticleBrain sciences2024

Differing Effects of Alcohol Use on Epigenetic and Brain Age in Adult Children of Parents with Alcohol Use Disorder.

Jamie L Scholl, Kami Pearson, Kelene A Fercho, Austin J Van Asselt, Noah A Kallsen, Erik A Ehli, Kari N Potter, Kathleen A Brown-Rice, Gina L Forster, Lee A Baugh

Abstract read
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In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jamie L SchollDivision of Basic Biomedical Sciences & Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.ORCID 0000-0002-1117-5290
Kami PearsonDivision of Basic Biomedical Sciences & Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Kelene A FerchoDivision of Basic Biomedical Sciences & Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Austin J Van AsseltAvera Institute for Human Genetics, Sioux Falls, SD 57105, USA.
Noah A KallsenAvera Institute for Human Genetics, Sioux Falls, SD 57105, USA.
Erik A EhliAvera Institute for Human Genetics, Sioux Falls, SD 57105, USA.ORCID 0000-0002-7865-3015
Kari N PotterMedical Laboratory Science, School of Health Sciences, University of South Dakota, Vermillion, SD 57069, USA.
Kathleen A Brown-RiceDepartment of Counselor Education, College of Education, Sam Houston State University, Huntsville, TX 77340, USA.
Gina L ForsterDepartment of Anatomy, University of Otago, Dunedin 9016, New Zealand.
Lee A BaughDivision of Basic Biomedical Sciences & Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.

Funding

SPURA - Summer Program for Undergraduate Research in AddictionR25DA033674 · NIDA · UNIVERSITY OF SOUTH DAKOTA · PI Bridget Diamond-Welch, Yohaan M. Fernandes · 2013 to 2026
$1.0M
NIDA NIH HHS R25 DA033674Summer Program for Undergraduate Research in Addiction (SPURA) fellowship NIH R25DA033674
6 · The paper itself

Abstract

backgroundIt is known that being the adult child of a parent with an alcohol use disorder (ACoA) can confer a wide variety of increased health and psychological risks, including higher rates of anxiety, depression, and post-traumatic stress disorder symptoms. Additionally, ACoAs are at greater risk of developing alcohol/substance use disorders (AUDs/SUDs) than individuals from families without a history of AUDs.

methodsACoA individuals with risky hazardous alcohol use (

resultsHazardous and non-hazardous ACoA groups had lower predicted brain ages than the healthy control group (

conclusionsThe results demonstrate a decreased brain age in the ACoAs compared to control, concurrent with increased epigenetic age specifically in the hazardous ACoA group, laying the foundation for future research to identify individuals with an increased susceptibility to developing hazardous alcohol use. Together, these results provide a better understanding of the associations between epigenetic factors, brain structure, and alcohol use disorders.

Indexed as

alcoholanxietybrain agemethylationmethylation ageMRI

Identifiers

PMID39766462
PMCPMC11674551

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.