Evidence map›Paper›PMID 39766425›Full record

ReviewBrain sciences2024

Determining the Predictors of Recurrence or Regrowth Following Spinal Astrocytoma Resection: A Systematic Review and Meta-Analysis.

Harry Hoang, Amine Mellal, Milad Dulloo, Ryan T Nguyen, Neil Nazar Al-Saidi, Hamzah Magableh, Alexis Cailleteau, Abdul Karim Ghaith, Victor Gabriel El-Hajj, Adrian Elmi-Terander

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Harry HoangFaculty of Medicine, Department of Clinical Neurosciences, University of Geneva, 1205 Geneva, Switzerland.
Amine MellalDepartment of Neurosurgery, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0009-0007-9864-5577
Milad DullooFaculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
Ryan T NguyenMayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-0785-2949
Neil Nazar Al-SaidiMayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0003-4411-6147
Hamzah MagablehMayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-4468-3515
Alexis CailleteauFaculty of Medicine, Department of Clinical Neurosciences, University of Geneva, 1205 Geneva, Switzerland.
Abdul Karim GhaithMayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-9600-609X
Victor Gabriel El-HajjMayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0001-9479-761X
Adrian Elmi-TeranderDepartment of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-3776-6136

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSpinal astrocytomas (SA) represent 30-40% of all intramedullary spinal cord tumors (IMSCTs) and present significant clinical challenges due to their aggressive behavior and potential for recurrence. We aimed to pool the evidence on SA and investigate predictors of regrowth or recurrence after surgical resection.

methodsA systematic review and meta-analysis were conducted on peer-reviewed human studies from several databases covering the field of SA. Data were collected including sex, age, tumor location, extent of resection, histopathological diagnosis, and adjuvant therapy to identify predictors of SA recurrence. Recurrence was defined as failure of local tumor control or regrowth after treatment.

resultsA total of 53 studies with 1365 patients were included in the meta-analysis. A postoperative deterioration in neurological outcomes, as assessed by the modified McCormick scale, was noted in most of the patients. The overall recurrence rate amounted to 41%. On meta-analysis, high-grade WHO tumors were associated with higher odds of recurrence (OR = 2.65; 95% CI: 1.87, 3.76;

conclusionsThe results highlight the significant importance of tumor grade and extent of resection in patient prognosis. The role of adjuvant radiotherapy remains unclear, with most studies suggesting no differences in outcomes, with limitations due to potential confounders.

Indexed as

adjuvant radiotherapymortalitypredictorsprognosisrecurrencespinal astrocytoma

Identifiers

PMID39766425
PMCPMC11726993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.