Evidence map›Paper›PMID 39766416›Full record

ArticleBrain sciences2024

Effects of Route Complexity and Lighting on Route Following in Alzheimer's Disease and Posterior Cortical Atrophy.

Amelia M Carton, Chris Frost, Teresa Poole, Biao Yang, Ian D McCarthy, Tatsuto Suzuki, Catherine Holloway, Robin Serougne, Derrick Boampong, Mary Pat Sullivan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amelia M CartonDementia Research Centre, Department of Neurodegeneration, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID 0000-0001-9962-067X
Chris FrostDepartment of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.ORCID 0000-0003-0098-9915
Teresa PooleDepartment of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Biao YangPedestrian Accessibility Movement Environment Laboratory, Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 6BT, UK.
Ian D McCarthyPedestrian Accessibility Movement Environment Laboratory, Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 6BT, UK.
Tatsuto SuzukiPedestrian Accessibility Movement Environment Laboratory, Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 6BT, UK.
Catherine HollowayPedestrian Accessibility Movement Environment Laboratory, Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 6BT, UK.ORCID 0000-0001-7843-232X
Robin SerougnePedestrian Accessibility Movement Environment Laboratory, Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 6BT, UK.
Derrick BoampongPedestrian Accessibility Movement Environment Laboratory, Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 6BT, UK.
Mary Pat SullivanFaculty of Education and Professional Studies, Nipissing University, North Bay, ON P1B 8L7, Canada.
Nick TylerPedestrian Accessibility Movement Environment Laboratory, Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 6BT, UK.ORCID 0000-0001-7079-1301
Sebastian CrutchDementia Research Centre, Department of Neurodegeneration, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID 0000-0002-4160-0139
Keir X X YongDementia Research Centre, Department of Neurodegeneration, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID 0000-0002-9708-3599

Funding

Alzheimer's Research UK ART-SRF2010-3 (Senior Research Fellowship)Alzheimer's Society AS-JF-18-003 (corresponding author fellowship funded by this grant)Economic and Social Research Council ES/L001810/1 (Grant from ESRC/NIHR)Engineering and Physical Sciences Research Council EP/M006093/1
6 · The paper itself

Abstract

objectiveVisual processing deficits arising in dementia are associated with particular functional disability. This study aimed to investigate the effects of the built environment on mobility and navigation in people with dementia-related visual loss.

methodsParticipants with posterior cortical atrophy (PCA; "visual-variant Alzheimer's"; n = 11), typical Alzheimer's disease (tAD; N = 10), and controls (n = 13) repeatedly walked down routes within a simplified real-world setting. Participant groups were of comparable age and gender. Routes were of different complexity (straight, U-shaped, and S-shaped), overhead lighting levels (low and high) and with or without a dynamic LED (light-emitting diode) cue (trial n = 24). Ratios of walking times for each experimental condition (each complex route vs the straight route, high lighting vs low, and LED cue vs no cue) were compared between participant groups. Kinematic measures were produced from a total of 10,813 steps using wearable inertial measurement units (IMUs).

resultsThe walking time ratios relating to route complexity were higher in the PCA group than in controls: 30.3% (95% CI [13.5%, 49.5%] higher for U-shaped vs straight and 31.9% [21.1%, 55.3%] for S-shaped vs straight, averaged over other conditions). The analogous results relating to route complexity for the tAD group were intermediate between those for the PCA and control groups. There was no evidence that walking time ratios differed according to lighting level or the presence of the LED cue.

conclusionsFindings contribute to evidence-based design for dementia-friendly environments, emphasizing consequences of environmental complexity for functional independence and mobility in people with dementia-related visual loss. Findings inform recommendations for environmental design to support the independence of individuals with dementia.

Indexed as

accessibilityAlzheimer’s diseasebuilt environmentdementiagaitinertial measurement unitsnavigation

Identifiers

PMID39766416
PMCPMC11726922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.