Evidence map›Paper›PMID 39766358›Full record

ArticleBiomolecules2024

PLGA-Nano-Encapsulated Disulfiram Inhibits Cancer Stem Cells and Targets Non-Small Cell Lung Cancer In Vitro and In Vivo.

Kate Butcher, Zhipeng Wang, Sathishkumar Kurusamy, Zaixing Zhang, Mark R Morris, Mohammad Najlah, Christopher McConville, Vinodh Kannappan, Weiguang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kate ButcherFaculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.
Zhipeng WangFaculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.
Sathishkumar KurusamyFaculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.
Zaixing ZhangFaculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.ORCID 0009-0003-6329-8676
Mark R MorrisFaculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.
Mohammad NajlahFaculty of Health, Medicine and Social Care, Anglia Ruskin University, Cambridge CB1 1PT, UK.ORCID 0000-0001-7670-2859
Christopher McConvilleSchool of Biomedical Sciences, Ulster University, Coleraine BT52 1SA, UK.
Vinodh KannappanFaculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.
Weiguang WangFaculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.ORCID 0000-0003-0509-2605

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) play a key role in non-small cell lung cancer (NSCLC) chemoresistance and metastasis. In this study, we used two NSCLC cell lines to investigate the regulating effect of hypoxia in the induction and maintenance of CSC traits. Our study demonstrated hypoxia-induced stemness and chemoresistance at levels comparable to those in typical CSC sphere culture. Activation of the NF-κB pathway (by transfection of NF-κB-p65) plays a key role in NSCLC CSCs and chemoresistance. Disulfiram (DS), an anti-alcoholism drug, showed a strong

Indexed as

Carcinoma, Non-Small-Cell LungDisulfiramLung NeoplasmsNanoparticlesNeoplastic Stem CellsPolylactic Acid-Polyglycolic Acid CopolymerAnimalsAntineoplastic AgentsCell Line, TumorDrug Resistance, NeoplasmHumansMiceMice, NudeXenograft Model Antitumor AssaysAntineoplastic AgentsDisulfiramPolylactic Acid-Polyglycolic Acid Copolymercancer stem cellschemoresistancecopper gluconatedisulfiramnon-small cell lung cancerPLGA nano-delivery

Identifiers

PMID39766358
PMCPMC11674892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.