Evidence map›Paper›PMID 39766332›Full record

ArticleBiomolecules2024

Installation of an Indole on the BRCA1 Disordered Domain Using Triazine Chemistry.

Liam E Claton, Chrissy Baker, Hayes Martin, Sergei V Dzyuba, Khadiza Zaman, Laszlo Prokai, Mikaela D Stewart, Eric E Simanek

Abstract read
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In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liam E ClatonDepartment of Chemistry & Biochemistry, Texas Christian University, Fort Worth, TX 76129, USA.
Chrissy BakerDepartment of Biology, Texas Christian University, Fort Worth, TX 76129, USA.
Hayes MartinDepartment of Biology, Texas Christian University, Fort Worth, TX 76129, USA.
Sergei V DzyubaDepartment of Chemistry & Biochemistry, Texas Christian University, Fort Worth, TX 76129, USA.
Khadiza ZamanDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0003-4876-765X
Laszlo ProkaiDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0002-4559-3458
Mikaela D StewartDepartment of Biology, Texas Christian University, Fort Worth, TX 76129, USA.ORCID 0000-0002-0809-9469
Eric E SimanekDepartment of Chemistry & Biochemistry, Texas Christian University, Fort Worth, TX 76129, USA.ORCID 0000-0002-3195-4523

Funding

Disrupting Protein-Protein Interactions with Self-Assembling MacrocyclesR15GM135900 · NIGMS · TEXAS CHRISTIAN UNIVERSITY · PI SIMANEK, ERIC E, STEWART, MIKAELA · 2019 to 2023
$736k
NIGMS NIH HHS R15 GM135900
6 · The paper itself

Abstract

The functionalization of protein sidechains with highly water-soluble chlorotriazines (or derivatives thereof) using nucleophilic aromatic substitution reactions has been commonly employed to install various functional groups, including poly(ethylene glycol) tags or fluorogenic labels. Here, a poorly soluble dichlorotriazine with an appended indole is shown to react with a construct containing the disordered domain of BRCA1. Subsequently, this construct can undergo proteolytic cleavage to remove the SUMO-tag: the

Indexed as

BRCA1 ProteinIndolesTriazinesCircular DichroismHumansProtein DomainsTumor Suppressor ProteinsBRCA1 ProteinBRCA1 protein, humanindoleIndolesTriazinesTumor Suppressor ProteinsBRCA1fluorescent labelsindoleprotein labelingprotein modificationtriazine

Identifiers

PMID39766332
PMCPMC11726873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.