Recycling of Uridylated mRNAs in Starfish Embryos.

Haruka Yamazaki, Megumi Furuichi, Mikoto Katagiri, Rei Kajitani, Takehiko Itoh, Kazuyoshi Chiba

Abstract read

In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Haruka YamazakiDepartment of Biological Sciences, Ochanomizu University, Bunkyo-ku, Tokyo 112-8610, Japan.

Megumi FuruichiDepartment of Biological Sciences, Ochanomizu University, Bunkyo-ku, Tokyo 112-8610, Japan.

Mikoto KatagiriDepartment of Biological Sciences, Ochanomizu University, Bunkyo-ku, Tokyo 112-8610, Japan.

Rei KajitaniSchool of Life Science and Technology, Institute of Science Tokyo, Meguro-ku, Tokyo 152-8550, Japan.ORCID 0000-0002-5013-0052

Takehiko ItohSchool of Life Science and Technology, Institute of Science Tokyo, Meguro-ku, Tokyo 152-8550, Japan.ORCID 0000-0002-6113-557X

Kazuyoshi ChibaDepartment of Biological Sciences, Ochanomizu University, Bunkyo-ku, Tokyo 112-8610, Japan.ORCID 0000-0003-0416-1090

Funding

the Takeda Science Foundation JSPS KAKENHI (JP17K07405, 21K06185 to K.C.) : the Cooperative Program provided by the Atmosphere and Ocean Research Institute, University of Tokyo

6 · The paper itself

Abstract

In eukaryotes, mRNAs with long poly(A) tails are translationally active, but deadenylation and uridylation of these tails generally cause mRNA degradation. However, the fate of uridylated mRNAs that are not degraded quickly remains obscure. Here, using tail-seq and microinjection of the 3' region of mRNA, we report that some mRNAs in starfish are re-polyadenylated to be translationally active after deadenylation and uridylation. In oocytes, uridylated maternal cyclin B mRNAs are stable without decay, and they are polyadenylated to be translated after hormonal stimulation to resume meiosis, whereas they are deadenylated and re-uridylated at the blastula stage, followed by decay. Similarly, deadenylated and uridylated maternal ribosomal protein mRNAs,

Indexed as

RNA, MessengerStarfishAnimalsCyclin BEmbryo, NonmammalianOocytesProtein BiosynthesisRibosomal ProteinsRNA StabilityCyclin BRibosomal ProteinsRNA, MessengerdeadenylationmRNA degradationpoly(A)ribosomal protein mRNAsstarfishuridylation

Identifiers

PMID39766317

DOI10.3390/biom14121610

PMCPMC11674185

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.