Evidence map›Paper›PMID 39766269›Full record

ArticleBiomolecules2024

Bioactivation, Mutagenicity, DNA Damage, and Oxidative Stress Induced by 3,4-Dimethylaniline.

Mariam R Habil, Raúl A Salazar-González, Mark A Doll, David W Hein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Impact ofBiomolecules · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mariam R HabilDepartment of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Raúl A Salazar-GonzálezDepartment of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Mark A DollDepartment of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
David W HeinDepartment of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.ORCID 0000-0003-3261-9775

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
Superfund Training CoreP42ES023716 · NIEHS · UNIVERSITY OF LOUISVILLE · PI HEIN, DAVID W · 2017 to 2025
$18.1M
UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1M
Strategic Vision & Impact on Environmental HealthP30ES014443 · NIEHS · UNIVERSITY OF LOUISVILLE · PI RAMOS, KENNETH S. · 2007 to 2010
$4.4M
NIEHS NIH HHS P30 ES014443NIEHS NIH HHS P42 ES023716NIEHS NIH HHS T32 ES011564NIGMS NIH HHS P20 GM113226This research was funded by National Institutes of Health (NIEHS [National Institute of Environmental Health Sciences] T32-ES011564, NIEHS P30-ES030283, NIEHS P42-ES023716, and NIGMS [National Institute of General Medical Sciences] P20-GM113226. T32-ES011564, P30-ES030283, P42-ES023716; P20-GM113226.
6 · The paper itself

Abstract

3,4-Dimethylaniline (3,4-DMA) is present in cigarette smoke and widely used as an intermediate in dyes, drugs, and pesticides. Nucleotide excision repair-deficient Chinese hamster ovary (CHO) cells stably transfected with human CYP1A2 and N-acetyltransferase 1 (NAT1) alleles:

Indexed as

Aniline CompoundsArylamine N-AcetyltransferaseCricetulusDNA DamageOxidative StressReactive Oxygen SpeciesAcetylationAnimalsCHO CellsCricetinaeCytochrome P-450 CYP1A2HumansHypoxanthine PhosphoribosyltransferaseIsoenzymesMutagens2,6-xylidineAniline CompoundsArylamine N-AcetyltransferaseCytochrome P-450 CYP1A2Hypoxanthine PhosphoribosyltransferaseIsoenzymesMutagensN-acetyltransferase 1Reactive Oxygen Species3,4-dimethylanilinedouble strand breaksgenotoxicitymutationsNAT1

Identifiers

PMID39766269
PMCPMC11674834

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.