Evidence map›Paper›PMID 39766215›Full record

ArticleBiomolecules2024

Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome.

Yuxun Zhang, Bob B Zhang, Sivakama S Bharathi, Joanna Bons, Jacob P Rose, Samah Shah, Steven F Dobrowolski, Sunder Sims-Lucas, Birgit Schilling, Eric S Goetzman

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Odd-Chain Dicarboxylic Acid Feeding Produces a Glutaric Aciduria Type 1-Like Metabolic Signature in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuxun ZhangDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA.ORCID 0000-0002-6682-012X
Bob B ZhangDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Sivakama S BharathiDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA.ORCID 0000-0003-0611-2778
Joanna BonsThe Buck Institute for Research on Aging, Novato, CA 94945, USA.ORCID 0000-0002-1110-4193
Jacob P RoseThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Samah ShahThe Buck Institute for Research on Aging, Novato, CA 94945, USA.ORCID 0000-0003-4688-1248
Steven F DobrowolskiDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Sunder Sims-LucasDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Birgit SchillingThe Buck Institute for Research on Aging, Novato, CA 94945, USA.ORCID 0000-0001-9907-2749
Eric S GoetzmanDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA.

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shuchang Silvia Liu · 2019 to 2026
$10.9M
Regulation of Peroxisomal Metabolism by Lysine AcylationR01DK090242 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOETZMAN, ERIC S · 2011 to 2024
$5.4M
The role of Sirtuin 5 in acute kidney injuryR01DK121758 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMS-LUCAS, SUNDER · 2020 to 2024
$2.3M
Dicarboxylic acid therapy for prevention of kidney injuryR01DK134346 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERIC S GOETZMAN, Sunder Sims-Lucas · 2024 to 2026
$1.9M
Optimizing medium-chain lipids for the treatment of long-chain fatty acid oxidation disordersR01HD103602 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOETZMAN, ERIC S · 2021 to 2025
$1.7M
Orbitrap Fusion Lumos ETD with FAIMS ProS10OD028654 · OD · BUCK INSTITUTE FOR RESEARCH ON AGING · PI SCHILLING, BIRGIT · 2020 to 2020
$1.1M
NICHD NIH HHS R01 HD103602NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK090242NIDDK NIH HHS R01 DK121758NIDDK NIH HHS R01 DK134346NIH HHS 1R01DK090242-15A1NIH HHS 1R01HD103602-03A1NIH HHS S10 OD028654
6 · The paper itself

Abstract

Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC

Indexed as

LiverMice, KnockoutPeroxisomesSirtuinsAcyl Coenzyme AAnimalsDicarboxylic AcidsFatty AcidsMaleMiceMice, Inbred C57BLOxidation-ReductionAcyl Coenzyme ADicarboxylic AcidsFatty AcidsSIRT5 protein, mouseSirtuinssuccinyl-coenzyme Afatty acid oxidationperoxisomesirtuin-5

Identifiers

PMID39766215
PMCPMC11673421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.