Evidence map›Paper›PMID 39766202›Full record

ReviewBiomolecules2024

Multifaceted Aspects of Dysfunctional Myelopoiesis in Cancer and Therapeutic Perspectives with Focus on HCC.

Andrea Arleo, Annapaola Montagner, Catia Giovannini, Fabrizia Suzzi, Fabio Piscaglia, Laura Gramantieri

Abstract readReview
In one paragraph

Review in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea ArleoDepartment of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy.ORCID 0000-0002-3262-7268
Annapaola MontagnerDepartment of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy.
Catia GiovanniniDepartment of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy.ORCID 0000-0003-1904-1577
Fabrizia SuzziDepartment of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy.ORCID 0000-0001-7632-064X
Fabio PiscagliaDepartment of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy.ORCID 0000-0001-8264-1845
Laura GramantieriDivision of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5187-9559

Funding

European Union funding project "Next Generation EU" Alma Idea 2022, intervention line B - CUP J33C22001420001Italian Ministry o University and Research 2022F8NS75_002- CUP F53D2300707000
6 · The paper itself

Abstract

Myelopoiesis provides for the formation and continued renewal of cells belonging primarily to the innate immune system. It is a highly plastic process that secures the response to external and internal stimuli to face acute and changing needs. Infections and chronic diseases including cancer can modulate it by producing several factors, impacting proliferation and differentiation programs. While the lymphocytic compartment has attracted major attention due to the role of adaptive immunity in anticancer immune response, in recent years, research has found convincing evidence that confirms the importance of innate immunity and the key function played by emergency myelopoiesis. Due to cancer's ability to manipulate myelopoiesis to its own advantage, the purpose of this review is to outline myelopoiesis processes within the tumor microenvironment and suggest possible therapeutic lines of research to restore the physiological functioning of the host's immune system, with a special outlook on hepatocellular carcinoma (HCC).

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMyelopoiesisTumor MicroenvironmentAnimalsHumansImmunity, Innateaberrant myelopoiesiscancerdysfunctional myelopoiesisemergency myelopoiesisimmune systeminflammation

Identifiers

PMID39766202
PMCPMC11673139

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.