Evidence map›Paper›PMID 39766187›Full record

ArticleBiomolecules2024

Analysis of Bacterial Metabolites in Breath Gas of Critically Ill Patients for Diagnosis of Ventilator-Associated Pneumonia-A Proof of Concept Study.

Wojciech Filipiak, Robert Włodarski, Karolina Żuchowska, Alicja Tracewska, Magdalena Winiarek, Dawid Daszkiewicz, Marta Marszałek, Dagmara Depka, Tomasz Bogiel

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Harnessing breath biomarkers for pneumonia diagnosis and prognosis.Expert review of respiratory medicine · 2026
    Review
  3. Article
  4. Profiling of Volatile Metabolites ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wojciech FilipiakDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, A. Jurasza 2 Str., 85-089 Bydgoszcz, Poland.ORCID 0000-0002-8696-0816
Robert WłodarskiDepartment of Anaesthesiology and Intensive Care, 10th Military Research Hospital and Polyclinic, Powstańców Warszawy 5 Str., 85-681 Bydgoszcz, Poland.ORCID 0009-0008-3633-3014
Karolina ŻuchowskaDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, A. Jurasza 2 Str., 85-089 Bydgoszcz, Poland.ORCID 0000-0001-9918-4708
Alicja TracewskaDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, A. Jurasza 2 Str., 85-089 Bydgoszcz, Poland.
Magdalena WiniarekDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, A. Jurasza 2 Str., 85-089 Bydgoszcz, Poland.
Dawid DaszkiewiczDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, A. Jurasza 2 Str., 85-089 Bydgoszcz, Poland.
Marta MarszałekDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, A. Jurasza 2 Str., 85-089 Bydgoszcz, Poland.
Dagmara DepkaDepartment of Microbiology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Maria Curie-Skłodowska 9 Str., 85-094 Bydgoszcz, Poland.ORCID 0000-0003-2387-9778
Tomasz BogielDepartment of Microbiology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Maria Curie-Skłodowska 9 Str., 85-094 Bydgoszcz, Poland.ORCID 0000-0001-6787-1378

Funding

NATIONAL SCIENCE CENTRE, POLAND 2017/26/D/NZ6/00136
6 · The paper itself

Abstract

Bacterial infection of the lower respiratory tract frequently occurs in mechanically ventilated patients and may develop into life-threatening conditions. Yet, existing diagnostic methods have moderate sensitivity and specificity, which results in the overuse of broad-spectrum antibiotics administered prophylactically. This study aims to evaluate the suitability of volatile bacterial metabolites for the breath-based test, which is used for diagnosing Ventilator-Associated Pneumonia (VAP). The in vitro experiments with pathogenic bacteria most prevalent in VAP etiology (i.e.,

Indexed as

Breath TestsCritical IllnessPneumonia, Ventilator-AssociatedAdultAgedBacteriaFemaleGas Chromatography-Mass SpectrometryHumansMaleMiddle AgedProof of Concept StudyRespiration, ArtificialROC CurveVolatile Organic CompoundsVolatile Organic CompoundsAcinetobacter baumanniibacteria metabolitesbreath analysisdiagnostic breath testEscherichia coliGC-MS metabolomicKlebsiella pneumoniaePseudomonas aeruginosaventilator-associated pneumonia (VAP)volatile biomarkers

Identifiers

PMID39766187
PMCPMC11727074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.