Evidence map›Paper›PMID 39766133›Full record

ReviewCancers2024

Metal Oxide Nanoparticles as Efficient Nanocarriers for Targeted Cancer Therapy: Addressing Chemotherapy-Induced Disabilities.

Mohamed Taha Yassin, Fatimah O Al-Otibi, Sarah A Al-Sahli, Mohammad S El-Wetidy, Sara Mohamed

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohamed Taha YassinDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-0997-8350
Fatimah O Al-OtibiDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-3629-5755
Sarah A Al-SahliDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0009-0002-3319-2400
Mohammad S El-WetidyCollege of Medicine Research Center, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-2725-4708
Sara MohamedBotany and Microbiology Department, Faculty of Science, Benha University, Benha 13511, Egypt.

Funding

King Salman center For Disability Research KSRG-2024-370
6 · The paper itself

Abstract

Cancer remains a predominant global health concern, necessitating effective treatment options. Conventional cancer therapies, particularly chemotherapy, often face constraints such as low selectivity, insufficient solubility, and multidrug resistance (MDR), which diminish effectiveness and exacerbate negative effects. Metal oxide nanoparticles (MONPs), such as iron oxide, zinc oxide, and copper oxide, offer a promising solution by enhancing targeted drug delivery, reducing systemic toxicity, and mitigating chemotherapy-induced disabilities like neurotoxicity and cardiotoxicity. Nanocarriers conjugated with drugs can improve drug delivery within the body and enhance their circulation in the bloodstream. Recent advancements in MONP synthesis and functionalization have further improved their stability and drug-loading capacity, making them a valuable tool in cancer treatment. MONPs have distinctive physicochemical characteristics, enabling better imaging, drug encapsulation, and targeted medication delivery to cancerous cells. These nanocarriers enhance treatment effectiveness through focused and controlled drug release, reducing off-target effects and addressing drug resistance. This review aims to explore the potential of MONPs as efficient nanocarriers for anticancer drugs, addressing limitations of traditional chemotherapy such as poor specificity, systemic toxicity, and drug resistance. Additionally, the review discusses recent advancements in MONP synthesis and functionalization, which enhance their stability, drug-loading capacity, and compatibility.

Indexed as

chemotherapydisabilitydrug deliverymetal oxide nanoparticlesnanocarrierstargeted delivery

Identifiers

PMID39766133
PMCPMC11674168

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.