Evidence map›Paper›PMID 39766099›Full record

ArticleCancers2024

Preferential Genetic Pathways Lead to Relapses in Adult B-Cell Acute Lymphoblastic Leukemia.

Josgrey Navas-Acosta, Alberto Hernández-Sánchez, Teresa González, Ángela Villaverde Ramiro, Sandra Santos, Cristina Miguel, Jordi Ribera, Isabel Granada, Mireia Morgades, Ricardo Sánchez and 13 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Josgrey Navas-AcostaIBSAL, IBMCC, CSIC, Centro de Investigación del Cáncer, University of Salamanca, 37007 Salamanca, Spain.ORCID 0009-0005-4678-0860
Alberto Hernández-SánchezIBSAL, IBMCC, CSIC, Centro de Investigación del Cáncer, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-6601-3096
Teresa GonzálezIBSAL, IBMCC, CSIC, Centro de Investigación del Cáncer, University of Salamanca, 37007 Salamanca, Spain.
Ángela Villaverde RamiroIBSAL, IBMCC, CSIC, Centro de Investigación del Cáncer, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-7337-7218
Sandra SantosIBSAL, IBMCC, CSIC, Centro de Investigación del Cáncer, University of Salamanca, 37007 Salamanca, Spain.
Cristina MiguelIBSAL, IBMCC, CSIC, Centro de Investigación del Cáncer, University of Salamanca, 37007 Salamanca, Spain.
Jordi RiberaICO-Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), 08916 Badalona, Spain.
Isabel GranadaICO-Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), 08916 Badalona, Spain.
Mireia MorgadesICO-Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), 08916 Badalona, Spain.ORCID 0000-0003-0295-2534
Ricardo SánchezDepartment of Hematology, Hospital Doce de Octubre Hospital, 28041 Madrid, Spain.ORCID 0000-0002-6383-0381
Esperanza SuchDepartment of Hematology, Hospital Universitari i Politecnic La Fe, 46026 Valencia, Spain.
Susana BarrenaDepartment of Cytometry, University of Salamanca, 37007 Salamanca, Spain.
Juana CiudadDepartment of Cytometry, University of Salamanca, 37007 Salamanca, Spain.
Julio DávilaService of Hematology, Hospital Nuestra Señora de Sonsoles, 05004 Ávila, Spain.ORCID 0000-0002-5185-2073
Natalia de Las HerasService of Hematology, Hospital Universitario de León, 24071 León, Spain.
Alfonso García-de CocaDepartment of Hematology, Hospital Clínico de Valladolid, 47003 Valladolid, Spain.ORCID 0000-0002-4942-060X
Jorge LabradorDepartment of Hematology, Hospital Universitario Burgos, 09006 Burgos, Spain.ORCID 0000-0002-3696-0287
José Antonio QueizánDepartment of Hematology, Hospital General de Segovia, 40002 Segovia, Spain.
Sandra MartínMolecular Biology Unit, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
Alberto OrfaoDepartment of Cytometry, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-0007-7230
Josep-María RiberaICO-Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), 08916 Badalona, Spain.ORCID 0000-0003-1042-6024
Rocío BenitoIBSAL, IBMCC, CSIC, Centro de Investigación del Cáncer, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-9781-4198
Jesús María Hernández-RivasIBSAL, IBMCC, CSIC, Centro de Investigación del Cáncer, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-9661-9371

Funding

Consejería Educación Junta Castilla y León SA118P20, SA198P24Fundación Mutua Madrileña FMM21/002 AP176752021Instituto de Investigación Biomédica de Salamanca -IBSAL-Herencia Juan Salvador Escudero IBPED21/00001Instituto de Salud Carlos III CM23/00101Pfizer Global Medical Grants 69383919Proyectos de Investigación del SACYL, Spain, Gerencia Regional de Salud de Castilla y León. GRS 2385/A/21, GRS 2386/A/21, GRS2506/A22, GRS2823/A1/2023Red Temática de Investigación Cooperativa en Cáncer (RTICC), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC CB16/12/00233) and Fondos FEDER (EU). RD12/0036/0069
6 · The paper itself

Abstract

Adult B-cell acute lymphoblastic leukemia (B-ALL) is characterized by genetic heterogeneity and a high relapse rate, affecting over 40% of adults. However, the mechanisms leading to relapse in adults are poorly understood. Forty-four adult B-ALL patients were studied at both diagnosis and relapse by next-generation sequencing (NGS). Four main genetic pathways leading to relapse in adults were identified:

Indexed as

B-cell ALLIZKF1plusmutational dynamicsNGSRAS mutationsrelapseTP53

Identifiers

PMID39766099
PMCPMC11674736

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.