Evidence map›Paper›PMID 39766040›Full record

ArticleCancers2024

Real-World Data of Patients with

Javier Ros, Jose Maria Ucha, Eduardo Garcia-Galea, Pablo Gomez, Giulia Martini, Francesca Balconi, Raquel Comas, Vicente Alonso, Marta Rodriguez, Iosune Baraibar and 6 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Javier RosMedical Oncology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0002-8137-5415
Jose Maria UchaMedical Oncology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0009-0008-3576-2861
Eduardo Garcia-GaleaVall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.ORCID 0000-0003-4699-0786
Pablo GomezMedical Oncology, Miguel Servet Hospital, 50009 Zaragoza, Spain.ORCID 0009-0006-6856-7013
Giulia MartiniDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Francesca BalconiMedical Oncology, University Hospital, University of Cagliari, 09124 Cagliari, Italy.
Raquel ComasVall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.
Vicente AlonsoMedical Oncology, Miguel Servet Hospital, 50009 Zaragoza, Spain.
Marta RodriguezMedical Oncology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0003-1935-0951
Iosune BaraibarMedical Oncology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0002-3500-9641
Francesc SalvaMedical Oncology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0001-9240-4907
Nadia SaoudiMedical Oncology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
Adriana AlcarazVall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.ORCID 0009-0002-5976-3312
Ariadna GarciaVall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.
Josep TaberneroMedical Oncology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0002-2495-8139
Elena ElezMedical Oncology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFor patients with refractory metastatic colorectal cancer (mCRC), trifluridine/tipiracil (FTD-TPI) has been associated with a significant improvement in overall survival (OS). However, data are lacking regarding the activity of FTD-TPI in patients with

methodsThis retrospective, multicenter, international cohort included patients with

resultsIn the 26 patients included, the median age was 61 years, 13 (50%) were female, and 20 (77%) had an Eastern Cooperative Oncology Group (ECOG) performance status of 1. Fourteen (56%) patients had right-sided tumors, six (23%) had microsatellite instability tumors, and thirteen (50%) had liver metastases. Median progression-free survival was 2.3 months (95% CI 2.0-3.2), and median OS (mOS) was 6.6 months (95% CI 4.4-12.0). mOS was 7.6 vs. 4.2 months (HR 1.64, 95% CI 0.65-4.10,

conclusionsPatients with

Indexed as

BRAF mutationcolorectal cancertrifluridine/tipiracil

Identifiers

PMID39766040
PMCPMC11674344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.