Evidence map›Paper›PMID 39765914›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Oxidative Stress, Inflammation and Altered Glucose Metabolism Contribute to the Retinal Phenotype in the Choroideremia Zebrafish.

Cécile Méjécase, Neelima Nair, Hajrah Sarkar, Pablo Soro-Barrio, Maria Toms, Sophia Halliday, Katy Linkens, Natalia Jaroszynska, Constance Maurer, Nicholas Owen and 1 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cécile MéjécaseDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.ORCID 0000-0003-2532-4004
Neelima NairDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Hajrah SarkarDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Pablo Soro-BarrioBioinformatics and Biostatistics Science Technology Platform, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0003-4509-6109
Maria TomsDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Sophia HallidayDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.ORCID 0000-0001-6537-5223
Katy LinkensDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Natalia JaroszynskaDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Constance MaurerDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Nicholas OwenDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.ORCID 0000-0001-5598-6274
Mariya MoosajeeDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.ORCID 0000-0003-1688-5360

Funding

Moorfields Eye Charity 569249.S-ACA.183882Retina UK GR594Wellcome TrustWellcome Trust 205174/Z/16/Z
6 · The paper itself

Abstract

Reactive oxygen species (ROS) within the retina play a key role in maintaining function and cell survival. However, excessive ROS can lead to oxidative stress, inducing dysregulation of metabolic and inflammatory pathways. The

Indexed as

CHMchoroideremiaglucose metabolisminherited retinal diseasesoxidative stresszebrafish

Identifiers

PMID39765914
PMCPMC11673030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.