Evidence map›Paper›PMID 39765897›Full record

ArticleAntioxidants (Basel, Switzerland)2024

The Focal Induction of Reactive Oxygen Species in Rats as a Trigger of Aortic Valve Degeneration.

Jessica Isabel Selig, Yukiharu Sugimura, Shintaro Katahira, Marco Polidori, Laura Alida Jacobi, Olga Medovoj, Sarah Betke, Mareike Barth, Artur Lichtenberg, Payam Akhyari and 1 more

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In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica Isabel SeligDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Yukiharu SugimuraDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Shintaro KatahiraDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Marco PolidoriDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Laura Alida JacobiDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Olga MedovojDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Sarah BetkeDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Mareike BarthDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Artur LichtenbergDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.ORCID 0000-0001-8580-6369
Payam AkhyariDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
Jan-Philipp MinolDepartment of Cardiac Surgery, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.

Funding

"Strategic Research Fund" of the Heinrich-Heine-University, Dusseldorf, Germany, in 2017 no Grant No.
6 · The paper itself

Abstract

backgroundDegenerative aortic valve disease (DAVD) is a multifactorial process. We developed an animal model to analyze the isolated, local effect of reactive oxygen species (ROS) on its pathophysiology.

methodsWe utilized a photodynamic reaction (PDR) as a source of ROS in the aortic valve by aiming a laser at the aortic valve for 60 min after the administration of a photosensitizer 24 h prior. ROS, laser, and sham groups (

resultsThe ROS group displayed an increased amount of ROS (

conclusionThe small animal model employed here may serve as a platform for analyzing ROS's isolated role in the DAVD context.

Indexed as

aortic valve stenosisdegenerative aortic valve diseasemTHCPphotodynamic reactionreactive oxygen speciestemoporfin

Identifiers

PMID39765897
PMCPMC11673780

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.