Evidence map›Paper›PMID 39765891›Full record

ReviewAntioxidants (Basel, Switzerland)2024

Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer.

Milagros Junco, Clara Ventura, Florencia Ximena Santiago Valtierra, Eduardo Nestor Maldonado

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators.Journal of enzyme inhibition and medicinal chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Milagros JuncoDepartment of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Clara VenturaInstitute for Immunological and Physiopathological Studies (IIFP), National Scientific and Technical Research Council (CONICET), Buenos Aires, La Plata 1900, Argentina.
Florencia Ximena Santiago ValtierraDepartment of Biology, Biochemistry and Pharmacy (DBByF), National University of the South (UNS), Bahia Blanca B8000, Argentina.ORCID 0000-0002-9954-8193
Eduardo Nestor MaldonadoDepartment of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-5285-3027

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
South Carolina COBRE in Oxidants, Redox Balance and Stress SignalingP30GM140964 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI EBLEN, SCOTT T · 2021 to 2025
$6.4M
VDAC-Tubulin Regulation of Mitochondrial Membrane Potential HeterogeneityR01CA184456 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MALDONADO, EDUARDO NESTOR · 2016 to 2020
$1.9M
NCATS NIH HHS UL1 TR001450NCI NIH HHS R01 CA184456NIGMS NIH HHS P30 GM140964NIH HHS RO1 CA184456Pilot Award in Redox and Oxidative Stress P30 GM140964-01South Carolina Translational Research Pilot Project UL1 TR001450-SCTR
6 · The paper itself

Abstract

Cancer metabolism is sustained both by enhanced aerobic glycolysis, characteristic of the Warburg phenotype, and oxidative metabolism. Cell survival and proliferation depends on a dynamic equilibrium between mitochondrial function and glycolysis, which is heterogeneous between tumors and even within the same tumor. During oxidative phosphorylation, electrons from NADH and FADH

Indexed as

antioxidantscancerlipid peroxidationmitochondriaoxidative stressROSVDAC

Identifiers

PMID39765891
PMCPMC11673973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.