ArticleBiology2024
Autoimmune Diseases and Molecular Mimicry in Tuberculosis.
Article in Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- QuantiFERON-TB gold test: a valuable diagnostic tool for tubercular uveitis in non-endemic regions.Infection · 2026Article
- Molecular Mimicry by the Tick-Borne Encephalitis Virus E Protein: A Hidden Link to Autoimmunity.International journal of molecular sciences · 2026Article
- Case Report: Rare factor V inhibitor found in a patient with ulcerative colitis during latent tuberculosis infection.Frontiers in medicine · 2026Article
- Reactive Arthritis Unmasked by Tuberculosis: A Rare Case of Poncet's Disease With Disseminated TB in a Malnourished Young Adult.Clinical case reports · 2025Article
- Undifferentiated inflammatory arthritis in a tuberculosis-positive patient: a diagnostic and therapeutic challenge - a case report.Annals of medicine and surgery (2012) · 2025Article
- Immunological testing and machine learning in detecting latent tuberculosis among high-risk groups (nature review).Frontiers in medicine · 2025Review
- Rheumatic diseases and latent tuberculosis infection in children: diagnostic and therapeutic challenges.Frontiers in cellular and infection microbiology · 2025Review
- The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Comorbidities in tuberculosis patients are increasing annually. Autoimmune pathology may influence the diagnosis and treatment of tuberculosis (TB). However, the molecular mimicry between MATERIALS AND
methodsWe analyzed the level of antibodies in 19 patients with pulmonary tuberculosis. In all cases ELISA assays was used. Also, in parallel, we identified 29 similar pentapeptides between key Mtb antigens and human autoantigens. Bioinformatic methods were used in this study. All amino acid sequences of MT antigens and human autoantigens were obtained from the UniProt database, and similar epitopes between Mtb antigens and human autoantigens were identified using the original "Alignmentaj" program. The immunoreactivity of the shared pentapeptides in Mtb antigens was evaluated with use of the IEDB database.
resultsThe high level of antibodies to modified citrulinated vimentin (anti-MCV) was most frequently detected (57%) in comparison with other antibodies. Elevated levels of antibodies to C3 complement fragments (47%) and rheumatoid factors (21%) in the absence of any rheumatic or autoimmune diseases are noteworthy. Several of the shared pentapeptides belong to the immunoreactive epitopes of Mtb antigens. The bioinformatic data correlated with our earlier studies of the levels of corresponding autoantibodies in the sera of TB patients.
conclusionOur findings on cross-reactivity and sequence similarity between the Mtb proteins and human autoantigens provide support for the role of antigen mimicry in TB-related autoimmunity.
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