ArticleBiology2024
Circadian Rhythms of Skin Surface Lipids and Physiological Parameters in Healthy Chinese Women Reveals Circadian Changes in Skin Barrier Function.
Article in Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Temporally Optimized Antioxidant Serums for Daytime Defense and Nighttime Repair: A Multicenter Clinical Investigation.Dermatology and therapy · 2026Article
- Bacterial Extracellular Vesicles as Regulators of the Gut Microbiome-Circadian Axis in Inflammatory and Metabolic Diseases.Journal of microbiology and biotechnology · 2026Review
- Skin Barrier Repair and Nursing Care in Patients with Atopic Dermatitis: A Narrative Review.International journal of general medicine · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundCircadian rhythms are driven by the biological clock, an endogenous oscillator that generates approximately 24 h cycles in mammals. The circadian regulation of the lipid metabolism plays a crucial role in overall metabolic health. An analysis of the correlation between the skin's physiological parameters and skin lipids can provide a better insight into the rhythmic changes in skin condition.
objectivesThe aim was to reveal how skin surface lipids (SSLs) participate in the regulation of circadian rhythms in the skin and the importance of the circadian oscillation of facial lipid molecules in maintaining epidermal homeostasis.
methodsChanges in SSLs were assessed using UPLC-QTOF-MS. The skin's physiological parameters were quantified using non-invasive instruments. Multivariate data analysis was employed to evaluate the differences.
resultsBoth skin surface lipids and physiological parameters exhibited certain circadian variation patterns. Four major lipid classes (fatty acids, glycerophospholipids, prenol lipids, saccharolipids) exhibited circadian rhythmic trends, with seven lipid subclasses contributing most significantly to the overall patterns observed. Among the physiological parameters assessed, sebum secretion, transepidermal water loss, moisture measurement value, and skin surface temperature exhibited sinusoidal circadian rhythms. Further analysis revealed significant correlations between fatty acids and saccharolipids with moisture measurement values, and between glycerolipids and pH value. In addition, lipids closely associated with the barrier such as unsaturated fatty acids and ceramide chain lengths correlated significantly with moisture measurement values.
conclusionsThrough correlation analysis, the study elucidates the influence of diurnal fluctuations in skin surface lipids on skin barrier function. These findings hold significant implications for understanding skin barrier impairment associated with circadian rhythm disruptions.
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