ArticleAnimals : an open access journal from MDPI2024
Orchiectomy Decreases Locomotor Activity and Delays the Expression of the Clock Protein PER1 in the Suprachiasmatic Nucleus in Rabbits.
Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The suprachiasmatic nucleus (SCN) is the master regulator of the circadian system, modulating the daily timing of physiological and behavioral processes in mammals. While SCN synchronization is primarily driven by environmental light signals, sex hormones, particularly androgens, have a crucial role in regulating behavioral and reproductive processes to align with daily or seasonal cycles. SCN cell populations express receptors for sex steroid hormones, contributing to circadian synchronization mechanisms. Specifically, the activation of androgen receptors in the SCN has been shown to modulate clock gene expression and influence circadian rhythms. Rabbits, widely used in experimental research, exhibit unique behavioral patterns, including plasticity in circadian typology and seasonal variations in testosterone secretion. In this study, we explored, in male rabbits, the effect of castration on the daily pattern of locomotor activity and the expression of the clock protein PERIOD 1 (PER1) in the SCN. Our results show that castration significantly reduces daily locomotor activity and PER1 expression in the SCN. Moreover, a 4 h delay in the acrophase of PER1 expression was observed. We conclude that androgens have an important role in SCN synchronization mechanisms, contributing to the organization of physiological and behavioral events in this species.
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