Evidence map›Paper›PMID 39765417›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities.

Hannah R Hudson, Xuehan Sun, Miranda E Orr

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Cellular Senescence of Patient-derived Fibroblasts Reveals the Mid-old Stage as a Critical Window for Transcriptomic Signatures Linked to Alzheimer's Disease Biomarkers and Classification.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  7. Review
  8. Translational Geroscience Strategies for Delaying Multimorbidity.ACS pharmacology & translational science · 2026
    Review
  9. Article
  10. Review
  11. Tau aggregation.Histology and histopathology · 2026
    Review
  12. Review
  13. Senotherapeutics for Brain Aging Management.Neurology international · 2025
    Review
  14. Entwined processes in Alzheimer's disease: Brain cellular senescence and Alzheimer's disease pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  15. Review
  16. Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hannah R HudsonDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Neurology, Washington University School of Medicine in St Louis, MO, USA. Electronic address: h.hudson@wustl.edu.
Xuehan SunDepartment of Neurology, Washington University School of Medicine in St Louis, MO, USA. Electronic address: sxuehan@wustl.edu.
Miranda E OrrDepartment of Neurology, Washington University School of Medicine in St Louis, MO, USA; St Louis VA Medical Center, St Louis, MO, USA. Electronic address: orr.m@wustl.edu.

Funding

Identification and Characterization of Senescent Cells in Molecular Subtypes of Alzheimer's DiseaseR01AG085182 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Miranda Ethel Orr, Bin Zhang · 2024 to 2026
$2.5M
High Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of LifeR01AG068293 · NIA · WASHINGTON UNIVERSITY · PI ORR, MIRANDA ETHEL · 2020 to 2025
$2.0M
Neuroscience Training at Wake ForestT32NS115704 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CZOTY, PAUL W. · 2021 to 2025
$1.4M
Cell Senescence and Death in Neurodegenerative DiseasesR21NS125171 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MILLIGAN, CAROL, ORR, MIRANDA ETHEL · 2021 to 2021
$426k
BLRD VA I01 BX005717NIA NIH HHS R01 AG068293NIA NIH HHS R01 AG085182NINDS NIH HHS R21 NS125171NINDS NIH HHS T32 NS115704
6 · The paper itself

Abstract

Cellular senescence is a cell state triggered by programmed physiological processes or cellular stress responses. Stress-induced senescent cells often acquire pathogenic traits, including a toxic secretome and resistance to apoptosis. When pathogenic senescent cells form faster than they are cleared by the immune system, they accumulate in tissues throughout the body and contribute to age-related diseases, including neurodegeneration. This review highlights evidence of pathogenic senescent cells in the brain and their role in Alzheimer's disease (AD), the leading cause of dementia in older adults. We also discuss the progress and challenges of senotherapies, pharmacological strategies to clear senescent cells or mitigate their toxic effects, which hold promise as interventions for AD and related dementias (ADRD).

Indexed as

Alzheimer DiseaseBrainCellular SenescenceAnimalsHumansSenotherapeuticsSenotherapeuticsAlzheimer's diseaseBiology of agingNeurescenceNeurodegenerationtau

Identifiers

PMID39765417
PMCPMC12047392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.