Evidence map›Paper›PMID 39765227›Full record

ArticleCurrent biology : CB2025

Multiple mechanisms of action for an extremely painful venom.

Lydia J Borjon, Luana C de Assis Ferreira, Jonathan C Trinidad, Sunčica Šašić, Andrea G Hohmann, W Daniel Tracey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Artemin sensitises mouse (Mus musculus) and naked mole-rat (Heterocephalus glaber) sensory neurons in vitro.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lydia J BorjonDepartment of Biology, Indiana University, Bloomington, IN 47405, USA; Gill Institute for Neuroscience, Indiana University, Bloomington, IN 47405, USA.
Luana C de Assis FerreiraGill Institute for Neuroscience, Indiana University, Bloomington, IN 47405, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.
Jonathan C TrinidadDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Sunčica ŠašićDepartment of Biology, Indiana University, Bloomington, IN 47405, USA; Gill Institute for Neuroscience, Indiana University, Bloomington, IN 47405, USA.
Andrea G HohmannGill Institute for Neuroscience, Indiana University, Bloomington, IN 47405, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA; Program in Neuroscience, Indiana University, Bloomington, IN 47405, USA.
W Daniel TraceyDepartment of Biology, Indiana University, Bloomington, IN 47405, USA; Gill Institute for Neuroscience, Indiana University, Bloomington, IN 47405, USA; Program in Neuroscience, Indiana University, Bloomington, IN 47405, USA. Electronic address: dtracey@iu.edu.

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Cale Whitworth · 2014 to 2026
$13.5M
CB2 Cannabinoid Mechanisms for Suppressing Opioid Tolerance and DependenceR01DA047858 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, MACKIE, KENNETH · 2019 to 2023
$2.6M
Molecular, Cellular, and Circuit Mechanisms of Nociception BehaviorR35GM148258 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI William D Tracey · 2023 to 2026
$1.6M
Mechanisms of signaling between the nervous and immune systems.F32AI157551 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI BORJON, LYDIA JOHANNA · 2021 to 2023
$213k
NIAID NIH HHS F32 AI157551NIDA NIH HHS R01 DA047858NIGMS NIH HHS R35 GM148258NIH HHS P40 OD018537
6 · The paper itself

Abstract

Evolutionary arms races can lead to extremely specific and effective defense mechanisms, including venoms that deter predators by targeting nociceptive (pain-sensing) pathways. The venom of velvet ants (Hymenoptera: Mutillidae) is notoriously painful. It has been described as "Explosive and long lasting, you sound insane as you scream. Hot oil from the deep fryer spilling over your entire hand."

Indexed as

AntsAnt VenomsDrosophila melanogasterNociceptionNociceptorsAnimalsDrosophila ProteinsLarvaAnt VenomsDrosophila ProteinsDasymutillaDEG/ENaCdegenerinDrosophilaepithelial sodium channelnociceptionpainpickpocket channelsvelvet antvenom

Identifiers

PMID39765227
PMCPMC12080746

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.