Evidence map›Paper›PMID 39764852›Full record

ArticleCell reports2025

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs.

Weili Miao, Douglas F Porter, Zurab Siprashvili, Ian D Ferguson, Luca Ducoli, Duy T Nguyen, Lisa A Ko, Vanessa Lopez-Pajares, Suhas Srinivasan, Audrey W Hong and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Regulation of RNA-binding proteins by small biomolecules.Nature reviews. Molecular cell biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Weili MiaoProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: wmiao001@stanford.edu.
Douglas F PorterProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Zurab SiprashviliProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Ian D FergusonProgram in Cancer Biology, Stanford University, Stanford, CA, USA.
Luca DucoliProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Duy T NguyenProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Lisa A KoProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Vanessa Lopez-PajaresProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Suhas SrinivasanProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Audrey W HongProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Yen-Yu YangDepartment of Chemistry, University of California, Riverside, Riverside, CA, USA.
Zhongwen CaoDepartment of Chemistry, University of California, Riverside, Riverside, CA, USA.
Robin M MeyersProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Jordan M MeyersProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Shiying TaoProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Yinsheng WangDepartment of Chemistry, University of California, Riverside, Riverside, CA, USA.
Paul A KhavariProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA; Program in Cancer Biology, Stanford University, Stanford, CA, USA; Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA. Electronic address: khavari@stanford.edu.

Funding

REGULATORS OF EPIDERMAL GENE EXPRESSIONR01AR045192 · NIAMS · STANFORD UNIVERSITY · PI PAUL KHAVARI · 1999 to 2026
$9.9M
Mechanisms of Epidermal Homeostasis and Early NeoplasiaR01AR043799 · NIAMS · STANFORD UNIVERSITY · PI PAUL KHAVARI · 1998 to 2026
$9.1M
Chemical Biology of DNA and RNA AlkylationR35ES031707 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2020 to 2026
$6.1M
Transcriptional Regulatory Complexes in Epidermal DifferentiationK01AR070895 · NIAMS · STANFORD UNIVERSITY · PI LOPEZPAJARES, VANESSA · 2017 to 2022
$709k
REGULATION OF SKIN HOMEOSTASIS BY RNA-BINDING PROTEINSK01AR082351 · NIAMS · STANFORD UNIVERSITY · PI PORTER, DOUGLAS F · 2023 to 2025
$369k
GLUCOSE BINDS RBPs TO REGULATE EPIDERMAL HOMEOSTASISK01AR084077 · NIAMS · STANFORD UNIVERSITY · PI Weili Miao · 2024 to 2026
$338k
BLRD VA I01 BX001409NIAMS NIH HHS K01 AR070895NIAMS NIH HHS K01 AR082351NIAMS NIH HHS K01 AR084077NIAMS NIH HHS R01 AR043799NIAMS NIH HHS R01 AR045192NIEHS NIH HHS R35 ES031707
6 · The paper itself

Abstract

Glucose binding can alter protein oligomerization to enable differentiation. Here, we demonstrate that glucose binding is a general capacity of DExD/H-box RNA helicases, including DDX50, which was found to be essential for the differentiation of diverse cell types. Glucose binding to conserved DDX50 ATP binding sequences altered protein conformation and dissociated DDX50 dimers. DDX50 monomers bound STAU1 to redirect STAU1 from an RNA-decay-promoting complex with UPF1 to a DDX50-STAU1 ribonuclear complex. DDX50 and STAU1 bound and stabilized a common set of essential pro-differentiation RNAs, including JUN, OVOL1, CEBPB, PRDM1, and TINCR, whose structures they also modified. These findings uncover a DDX50-mediated mechanism of reprograming STAU1 from its canonical role in Staufen-mediated mRNA decay to an opposite role stabilizing pro-differentiation RNAs and establish an activity for glucose in controlling RNA structure and stability.

Indexed as

Cell DifferentiationCytoskeletal ProteinsDEAD-box RNA HelicasesRNA-Binding ProteinsRNA StabilityAnimalsGlucoseHEK293 CellsHumansMiceProtein BindingRNA HelicasesTrans-ActivatorsCytoskeletal ProteinsDEAD-box RNA HelicasesGlucoseRNA-Binding ProteinsRNA HelicasesSTAU1 protein, humanTrans-ActivatorsUPF1 protein, humanCP: Molecular biologyDDX50glucosemRNA stabilityRNA helicaseSTAU1tissue differentiation

Identifiers

PMID39764852
PMCPMC11875220

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.