Evidence map›Paper›PMID 39764544›Full record

ArticleEClinicalMedicine2024

Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review.

Mohsan Subhani, Ashwin Dhanda, James A King, Fiona C Warren, Siobhan Creanor, Melanie J Davies, Sally Eldeghaidy, Stephen Bawden, Penny A Gowland, Ramon Bataller and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Firewater, fructose and appetite.Nature metabolism · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mohsan SubhaniNottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK.
Ashwin DhandaFaculty of Health, University of Plymouth, Plymouth PL4 8AA, UK.
James A KingNational Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.
Fiona C WarrenFaculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QJ, UK.
Siobhan CreanorFaculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QJ, UK.
Melanie J DaviesNIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, UK.
Sally EldeghaidySir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2UH, UK.
Stephen BawdenSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2UH, UK.
Penny A GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2UH, UK.
Ramon BatallerLiver Unit, Hospital Clinic, Barcelona, Spain.
Justin GreenwoodNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2UH, UK.
Stephen KaarDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, M139WL, UK.
Neeraj BhalaNottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK.
Guruprasad P AithalNottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite the availability of various pharmacological and behavioural interventions, alcohol-related mortality is rising. This systematic review aimed to critically evaluate the existing literature on the association between glucagon-like peptide-1 receptor agonists use (GLP-1 RAs) and alcohol consumption. Methods: Electronic searches were conducted on Ovid Medline, EMBASE, PsycINFO, clintrials.gov, and ProQuest until the end of March 2024. An updated search was done on 7th of August 2024. The primary outcome was to explore the association between GLP-1 RAs use and change in alcohol consumption. Secondary outcomes included evaluating the impact of GLP-1 RAs on occurrences of alcohol-related events, healthcare utilisation, and the effect on functional magnetic resonance imaging (fMRI) cue reactivity. This study is registered with PROSPERO #CRD42024531982. Findings: Six studies totalling 88,190 participants were included with 38,740 (43.9%) receiving GLP-1 RA, but only 286 participated in randomised controlled trials. Pooled mean age was 49.6 years (SD = 10.5). RCT data did not show a reduction in alcohol consumption over 30 days after 24 weeks of treatment with exenatide versus placebo (heavy drinking days 6.0 [higher in control group], 95% CI -7.4 to 19.4, p = 0.37), a subgroup analysis found a positive effect in people with obesity (BMI >30 kg/m Interpretation: There is little high-quality evidence demonstrating the effect of GLP-1 RAs on alcohol use. Subgroup analysis from two RCTs and supporting data from four observational studies suggest that GLP-1 RAs may reduce alcohol consumption and improve outcomes in some individuals. Heterogeneous study findings warrant further research to establish the effectiveness and safety of GLP-1 RAs in this population. Funding: National Institute for Health and Care Research (NIHR): Award-ID: NIHR155469; NIHR154191; NIHR155530. NIHR Nottingham Biomedical Research Centre, Award-ID: BRC-1215-20003.

Indexed as

AlcoholismAlcohol useGLP-1 agonistGlucagon-like peptide-1 receptor agonistsSystematic review

Identifiers

PMID39764544
PMCPMC11701477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.