Evidence map›Paper›PMID 39764455›Full record

ArticleFrontiers in microbiology2024

WhiA transcription factor provides feedback loop between translation and energy production in a genome-reduced bacterium.

Gleb Y Fisunov, Vladimir B Tsvetkov, Ekaterina A Tsoy, Daria V Evsyutina, Alexey D Vedyaykin, Irina A Garanina, Tatiana A Semashko, Valentin A Manuvera, Anna M Varizhuk, Sergey I Kovalchuk and 4 more

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Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gleb Y FisunovScientific Research Institute of Systems Biology and Medicine, Moscow, Russia.
Vladimir B TsvetkovFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Ekaterina A TsoyScientific Research Institute of Systems Biology and Medicine, Moscow, Russia.
Daria V EvsyutinaScientific Research Institute of Systems Biology and Medicine, Moscow, Russia.
Alexey D VedyaykinPeter the Great St. Petersburg Polytechnic University, Saint Petersburg, Russia.
Irina A GaraninaFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Tatiana A SemashkoScientific Research Institute of Systems Biology and Medicine, Moscow, Russia.
Valentin A ManuveraFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Anna M VarizhukFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Sergey I KovalchukShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Alexander I ZubovFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Nicolay A BarinovFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Olga V PobegutsFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Vadim M GovorunScientific Research Institute of Systems Biology and Medicine, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: WhiA is a conserved protein found in numerous bacteria. It consists of an HTH DNA-binding domain linked with a homing endonuclease (HEN) domain. WhiA is one of the most conserved transcription factors in reduced bacteria of the class Mollicutes. Its function in Mollicutes is unknown, while it is well-characterized in Methods: We used a combination molecular dynamics, EMSA, MST and AFM to study the DNA-binding and ATP-binding properties of WhiA from Results: We demonstrate that WhiA homolog from M. gallisepticum binds a conserved sequence of the GAYACRCY core (Y = C or T, R = A or G), which is located in the promoter of an operon coding for ribosomal proteins and adenylate kinase ( Discussion: We propose the following model for

Indexed as

energy metabolismminimal cellMollicutesmycoplasmaribosomal proteinstranscription factor

Identifiers

PMID39764455
PMCPMC11701221

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