Evidence map›Paper›PMID 39764282›Full record

ArticleFrontiers in cardiovascular medicine2024

Yes-associated protein-based detection of acute type A aortic dissection and evaluation of therapeutic responses.

Kai Zhu, Hao-Xi Li, Dong-Dong Wu, Si-Chong Qian, Xiao-Long Wang, Jian-Rong Li, Wen-Jian Jiang, Hong Liu, Hai-Yang Li, Hong-Jia Zhang

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Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Kai Zhu *Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Hao-Xi Li *School of Public Health, Capital Medical University, Beijing, China.
Dong-Dong Wu *Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Si-Chong QianDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Xiao-Long WangDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Jian-Rong LiDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Wen-Jian JiangDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Hong LiuDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hai-Yang LiDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Hong-Jia ZhangDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute aortic dissection is a lethal cardiovascular emergency; early diagnosis is critically necessary. Novel serum biomarkers can potentially help in early detection and estimation of postoperative outcomes. Yes-associated protein (YAP) is a critical effector of the Hippo pathway, our aim was to explore the association between YAP and the diagnosis and prognosis of AD. Methods: We prospectively recruited 110 consecutive chest-pain patients [acute type A aortic dissection (ATAAD), Results: YAP concentration was substantially elevated among ATAAD patients [3.45 (3.18, 3.63) vs. 2.44 (2.23, 2.59), Conclusions: The serum YAP concentration is an early and sensitive serum bioindicator for distinguishing AAD from ACS. Moreover, the amount of postoperative circulating YAP is a robust indicator of postoperative MAEs.

Indexed as

acute aortic dissection (AAD)acute coronary syndrome (ACS)early diagnosismajor adverse events (MAEs)yes-associated protein (YAP)

Identifiers

PMID39764282
PMCPMC11701146

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