Evidence map›Paper›PMID 39764142›Full record

ArticleResearch square2024

Triple coding in human SRD5A1 mRNA.

Martina M Yordanova, Conor Slattery, Mirriam Baranova-Gurvich, Manon Engels, Oscar Ting, Michał Świrski, Jack A S Tierney, Håkon Tjeldnes, Jonathan Mudge, Gary Loughran and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Martina M YordanovaUniversity College Cork.
Conor SlatteryUniversity College Cork.
Mirriam Baranova-GurvichUniversity College Cork.
Manon EngelsUniversity College Cork.
Oscar TingUniversity College Cork.
Michał ŚwirskiUniversity of Warsaw.
Jack A S TierneyUniversity College Cork.
Håkon TjeldnesUniversity College Cork.
Jonathan MudgeEuropean Bioinformatics Institute.
Gary LoughranUniversity College Cork.
Dmitry E AndreevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS.
Pavel V BaranovUniversity College Cork.

Funding

GENCODE Resource ProjectU41HG007234 · NHGRI · SANGER INSTITUTE · PI FLICEK, PAUL · 2013 to 2020
$20.3M
NHGRI NIH HHS U41 HG007234Wellcome Trust
6 · The paper itself

Abstract

Background: Nucleotide sequence can be translated in three reading frames from 5' to 3' producing distinct protein products. Many examples of RNA translation in two reading frames (dual coding) have been identified so far. Results: We report simultaneous translation of mRNA transcripts derived from Conclusion: We argue for the importance of identification, characterisation and annotation of productive RNA translation irrespective of the presumed biological roles of the products of this translation.

Indexed as

gene annotationOverlapping genesprotein synthesisribosome decision graphsSRD5A1translation controltranslation initiationtranslonuORF

Identifiers

PMID39764142
PMCPMC11702784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.