Evidence map›Paper›PMID 39764048›Full record

ArticlebioRxiv : the preprint server for biology2024

Widespread Distribution of α-Synuclein Oligomers in

Hiroaki Sekiya, Lukas Franke, Yuki Hashimoto, Mariko Takata, Katsuya Nishida, Naonobu Futamura, Kazuko Hasegawa, Hisatomo Kowa, Owen A Ross, Pamela J McLean and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Hiroaki SekiyaDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0001-9683-5966
Lukas FrankeDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Yuki HashimotoDivision of Neurology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Mariko TakataDivision of Neurology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Katsuya NishidaDepartment of Neurology, National Hospital Organization Hyogo Chuo National Hospital, Sanda, Hyogo, Japan.ORCID 0000-0003-4978-5382
Naonobu FutamuraDepartment of Neurology, National Hospital Organization Hyogo Chuo National Hospital, Sanda, Hyogo, Japan.
Kazuko HasegawaDepartment of Neurology, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan.
Hisatomo KowaDivision of Neurology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.ORCID 0000-0002-5300-8589
Owen A RossDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0003-4813-756X
Pamela J McLeanDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0003-4870-5715
Tatsushi TodaDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-0717-1123
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0001-5487-1053
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0001-7189-7917

Funding

THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Utilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM, MCLEAN, PAMELA J · 2019 to 2023
$14.5M
Neuropathology CoreP50NS072187 · NINDS · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM · 2010 to 2017
$8.7M
NIA NIH HHS P50 AG016574NINDS NIH HHS P50 NS072187NINDS NIH HHS U54 NS110435
6 · The paper itself

Abstract

Mutations in leucine-rich repeat kinase 2 (

Indexed as

Alpha-synucleinLewy bodiesLRRK2OligomersParkinson diseasePathogenesis

Identifiers

PMID39764048
PMCPMC11702646

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.