Evidence map›Paper›PMID 39764034›Full record

ArticlebioRxiv : the preprint server for biology2024

Dynamic Changes in Gene Expression Through Aging in

Katherine M Hanson, Stuart J Macdonald

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Katherine M HansonDepartment of Molecular Biosciences and Center for Genomics, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.
Stuart J MacdonaldDepartment of Molecular Biosciences and Center for Genomics, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.ORCID 0000-0002-9421-002X

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Synthetic Chemical Biology CoreP30GM145499 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Susan M Lunte · 2022 to 2026
$6.9M
A Resource for the Genetic Dissection of Complex TraitsR01OD034064 · OD · UNIVERSITY OF KANSAS LAWRENCE · PI ANTHONY Douglas LONG, Stuart John Macdonald · 2023 to 2026
$2.4M
Evaluating a powerful genetic mapping framework to discover lifespan extension genes in DrosophilaR21AG086734 · NIA · UNIVERSITY OF KANSAS LAWRENCE · PI LONG, ANTHONY DOUGLAS, MACDONALD, STUART JOHN · 2024 to 2025
$425k
NIA NIH HHS R21 AG086734NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P30 GM145499NIH HHS R01 OD034064
6 · The paper itself

Abstract

Work in many systems has shown large-scale changes in gene expression during aging. However, many studies employ just two, arbitrarily-chosen timepoints at which to measure expression, and can only observe an increase or a decrease in expression between "young" and "old" animals, failing to capture any dynamic, non-linear changes that occur throughout the aging process. We used RNA sequencing to measure expression in male head tissue at 15 timepoints through the lifespan of an inbred

Indexed as

agingGene expressiongene ontology enrichmentlifespan

Identifiers

PMID39764034
PMCPMC11702523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.