ArticlebioRxiv : the preprint server for biology2024
Hyperactive PLCG1 drives non-canonical signaling to promote cell survival.
Longhui Zeng, Xinyan Zhang, Yiwei Xiong, Kazuki Sato, Nicole Hajicek, John Sondek, Xiaolei Su
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Longhui ZengDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA.
Xinyan ZhangDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA.
Yiwei XiongDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA.
Kazuki SatoDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA.
Nicole HajicekDepartment of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
John SondekDepartment of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MYale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI RUTH HALABAN · 2006 to 2026
$43.9MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MProgramming cellular behavior by mechanical forcesR01EB037112 · NIBIB · YALE UNIVERSITY · PI Julien Berro, Alexander Arthur Green · 2024 to 2026
$7.2MSpatial Organization of Membrane SignalingR35GM138299 · NIGMS · YALE UNIVERSITY · PI SU, XIAOLEI · 2020 to 2024
$2.3MA high-throughput platform to identify selective allosteric inhibitors of the PLC-y isozymesR01CA258993 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEARCE, KENNETH HUGH, SONDEK, JOHN E · 2021 to 2024
$2.2MPhospholipase C IsozymesR35GM149299 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOHN E SONDEK · 2023 to 2026
$1.7MDiscovery of allosteric activators of phospholipase C-gamma2 to treat Alzheimer's diseaseR56AG083424 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEARCE, KENNETH HUGH, SONDEK, JOHN E · 2023 to 2024
$1.5MCAR mast cell for solid tumorR21CA286364 · NCI · YALE UNIVERSITY · PI SU, XIAOLEI · 2024 to 2025
$438kNCI NIH HHS P30 CA016086NCI NIH HHS P50 CA121974NCI NIH HHS R01 CA258993NCI NIH HHS R21 CA286364NIA NIH HHS R56 AG083424NIBIB NIH HHS R01 EB037112NIDDK NIH HHS P30 DK034989NIGMS NIH HHS R35 GM138299NIGMS NIH HHS R35 GM149299
6 · The paper itselfAbstract
One of the long-standing questions in cell signaling field to identify and characterize key signaling nodes out of a complex network. Phospholipase Cγ1 (
Indexed as
ActinCondensationERKPLCG1T cell
Identifiers
PMID39763946
PMCPMC11702640
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390