Evidence map›Paper›PMID 39763931›Full record

ArticlebioRxiv : the preprint server for biology2025

Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions.

Tien Phuoc Tran, Bogdan Budnik, John E Froberg, Jeffrey D Macklis

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tien Phuoc TranDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-3354-5907
Bogdan BudnikWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID 0000-0003-3622-2003
John E FrobergDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.
Jeffrey D MacklisDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-3662-9698

Funding

Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and RegenerationDP1NS106665 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2017 to 2021
$5.9M
Molecular Controls over Neurogenesis, Subtype Development, and Diversity of Cortical Output Projection NeuronsR01NS045523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2002 to 2020
$5.4M
Subcellular mechanisms of subtype-specific neuron vulnerability in ALS and FTD: dysregulation of synapse-localized RNA, protein, and translation in mouse models and human cortico-spinal assembloidsRF1AG083085 · NIA · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2023 to 2023
$2.0M
Molecular Development and Diversity of Callosal Projection NeuronsR01NS104055 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2020 to 2024
$1.9M
NIA NIH HHS RF1 AG083085NINDS NIH HHS DP1 NS106665NINDS NIH HHS R01 NS045523NINDS NIH HHS R01 NS104055
6 · The paper itself

Abstract

Diverse subtypes of cortical projection neurons (PN) form long-range axonal projections that are responsible for distinct sensory, motor, cognitive, and behavioral functions. Translational control has been identified at multiple stages of PN development, but how translational regulation contributes to formation of distinct, subtype-specific long-range circuits is poorly understood. Ribosomal complexes (RCs) exhibit variations of their component proteins, with an increasing set of examples that confer specialized translational control. Here, we directly compare the protein compositions of RCs

Identifiers

PMID39763931
PMCPMC11703261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.