ArticlebioRxiv : the preprint server for biology2024
An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional Regulation.
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Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 citing paper in PubMed.
- Melatonin receptor signaling in human pathologies: from molecular mechanisms to therapeutic targets.Function (Oxford, England) · 2026Review
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Authors and funding
42 authors.
Jill E MooreDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3023-0806
Henry E PrattDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-9413-834X
Kaili FanDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-8723-7902
Nishigandha PhalkeDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-3980-6450
Jonathan FisherDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0009-0000-5858-9936
Shaimae I ElhajjajyDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-7497-5519
Gregory AndrewsDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-9880-3965
Mingshi GaoDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-7524-892X
Nicole SheddDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-2272-5398
Yu FuDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-6252-3075
Matthew C LacadieDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0009-0005-1650-622X
Jair MezaDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0009-0002-2244-9696
Mohit GannaDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Eva ChoudhuryDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Ross SwoffordDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Nina P FarrellBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-5452-2344
Anusri PampariDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6579-4070
Vivekanandan RamalingamDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3631-8913
Fairlie ReeseDevelopmental and Cell Biology, University of California Irvine, Irvine, USA.
Beatrice BorsariProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID 0000-0003-4357-3557
Michelle YuProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID 0000-0003-0307-530X
Eve WattenbergProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID 0009-0001-7815-681X
Marina Ruiz-RomeroCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, Barcelona, Catalonia, Spain.ORCID 0000-0002-8382-1052
Milad Razavi-MohseniDepartment of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-6052-3159
Jinrui XuProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID 0000-0003-1944-2821
Timur GaleevProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID 0000-0002-6241-1011
Michael A BeerDepartment of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-9955-3809
Roderic GuigóCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, Barcelona, Catalonia, Spain.ORCID 0000-0002-5738-4477
Mark GersteinProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID 0000-0002-9746-3719
Jesse EngreitzDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5754-1719
Mats LjungmanDepartments of Radiation Oncology and Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1553-6695
Timothy E ReddyDuke Center for Statistical Genetics and Genomics, Duke University, Durham, NC, USA.ORCID 0000-0002-7629-061X
Michael P SnyderDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0784-7987
Charles B EpsteinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8358-8345
Elizabeth GaskellBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6497-6211
Bradley E BernsteinBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Diane E DickelEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0001-5497-6824
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-4130-7784
Len A PennacchioEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-8748-3732
Ali MortazaviDevelopmental and Cell Biology, University of California Irvine, Irvine, USA.ORCID 0000-0002-4259-6362
Anshul KundajeDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3084-2287
Zhiping WengDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3032-7966
Funding
PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOMEUM1HG009442 · NHGRI · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2017 to 2021
$20.1MHigher Precision Human and Mouse TranscriptomesUM1HG009443 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MORTAZAVI, SEYED ALI, WOLD, BARBARA J · 2017 to 2021
$15.5MA Catalog of Cell Types and Genomic Elements in Tissues, Organoids and DiseaseUM1HG009390 · NHGRI · BROAD INSTITUTE, INC. · PI BERNSTEIN, BRADLEY EVAN · 2017 to 2021
$11.0MEDAC: ENCODE Data Analysis CenterU24HG009446 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GERSTEIN, MARK BENDER, WENG, ZHIPING · 2017 to 2022
$10.4MIn Vivo Characterization of Major ENCODE-Predicted Classes of Noncoding ElementsUM1HG009421 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2017 to 2021
$6.8MRegulatory Mechanisms of CD4+ T Cell DifferentiationUM1HG009428 · NHGRI · DUKE UNIVERSITY · PI CIOFANI, MARIA, CRAWFORD, GREGORY E · 2017 to 2021
$4.6MA Comprehensive Genomic Community Resource of Transcriptional RegulationU24HG012343 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Anshul Kundaje, Zhiping Weng · 2022 to 2026
$4.6MSystematic Identification of Core Regulatory Circuitry from ENCODE DataU01HG009380 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI BEER, MICHAEL A · 2017 to 2021
$2.6MMapping of Novel Candidate Functional Elements with Bru-Seq TechnologyUM1HG009382 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LJUNGMAN, MATS · 2017 to 2021
$2.3MNHGRI NIH HHS U01 HG009380NHGRI NIH HHS U24 HG009446NHGRI NIH HHS U24 HG012343NHGRI NIH HHS UM1 HG009382NHGRI NIH HHS UM1 HG009390NHGRI NIH HHS UM1 HG009421NHGRI NIH HHS UM1 HG009428NHGRI NIH HHS UM1 HG009442NHGRI NIH HHS UM1 HG009443
Abstract
Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated these data to develop a Registry of 0.9 million human and 300 thousand mouse candidate cis-Regulatory Elements (cCREs) annotated with potential functions
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.