Evidence map›Paper›PMID 39763810›Full record

ArticlebioRxiv : the preprint server for biology2024

Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice.

Robert N Helsley, Mikala M Zelows, Victoria P Noffsinger, Garrett B Anspach, Nikitha Dharanipragada, Anna E Mead, Isidoro Cobo, Abigail Carter, Qinglin Wu, Irina Shalaurova and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Mikala M Zelows
Victoria P Noffsinger
Garrett B Anspach
Nikitha Dharanipragada
Anna E Mead
Isidoro Cobo
Abigail Carter
Qinglin Wu
Irina Shalaurova
Kai Saito
Scott M Gordon
Gregory A Graf

Funding

Contributions of Hepatic and Intestinal Pathways to Cholesterol ExcretionR01DK113625 · NIDDK · UNIVERSITY OF KENTUCKY · PI Gregory A Graf · 2017 to 2026
$4.2M
The Role of DENND5B in Dietary Lipid AbsorptionR01DK133184 · NIDDK · UNIVERSITY OF KENTUCKY · PI Scott M Gordon · 2022 to 2026
$2.5M
Functional Interactions Between Lipoproteins and Protease Inhibitors in AtherosclerosisR01HL171111 · NHLBI · UNIVERSITY OF KENTUCKY · PI Scott M Gordon · 2024 to 2026
$1.9M
Elucidating Molecular Mechanisms Linking Fructose to Cholesterol MetabolismK01DK128022 · NIDDK · UNIVERSITY OF KENTUCKY · PI Robert Nathaniel Helsley · 2022 to 2026
$647k
NHLBI NIH HHS R01 HL171111NIDDK NIH HHS K01 DK128022NIDDK NIH HHS R01 DK113625NIDDK NIH HHS R01 DK133184
6 · The paper itself

Abstract

Genome- and epigenome-wide association studies have associated variants and methylation status of carnitine palmitoyltransferase 1a (CPT1a) to reductions in very low-density lipoprotein (VLDL) cholesterol and triglyceride levels. We report significant associations between the presence of HIGHLIGHTS: Loss-of-function SNPs in

Identifiers

PMID39763810
PMCPMC11702516

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.