ArticlebioRxiv : the preprint server for biology2025
Inhibition of Renin Release, a Crucial Event in Homeostasis, is Mediated by Coordinated Calcium Oscillations within Juxtaglomerular Cell Clusters.
Hiroki Yamaguchi, Nick A Guagliardo, Laura A Bell, Manako Yamaguchi, Daisuke Matsuoka, Fang Xu, Jason P Smith, Mohamed Diagne, Lucas F Almeida, Silvia Medrano and 4 more
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In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Hiroki YamaguchiDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0003-2409-7401 Nick A GuagliardoDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0003-2539-1346 Laura A BellDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0003-0659-5650 Manako YamaguchiDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-2880-9165 Daisuke MatsuokaDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-2164-0555 Fang XuDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0009-0009-5330-7392 Jason P SmithDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-2688-0988 Mohamed DiagneDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0009-0002-5801-9997 Lucas F AlmeidaDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-5731-1219 Silvia MedranoDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-8516-0788 Paula Q BarrettDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0003-2052-3899 Edward H NiehDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0003-2154-6224 R Ariel GomezDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-5124-8255 Maria Luisa S Sequeira-LopezDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-4459-7940 Funding
Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8MPlasticity of renin cells in the kidney vasculatureR01DK116718 · NIDDK · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2018 to 2022
$2.8MRenin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7MCharacterizing the underlying population code to understand the functional organization of the hippocampus and the lateral hypothalamusR00DA053388 · NIDA · UNIVERSITY OF VIRGINIA · PI NIEH, HORNG-AN EDWARD · 2023 to 2025
$747kInvestigating the role of NG2-glia in the development of epilepsyK00NS125773 · NINDS · UNIVERSITY OF VIRGINIA · PI Laura Ann Bell · 2023 to 2026
$362kNHLBI NIH HHS R01 HL148044NIDA NIH HHS R00 DA053388NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK116718NINDS NIH HHS K00 NS125773
6 · The paper itselfAbstract
backgroundJuxtaglomerular (JG) cells are sensors that control blood pressure (BP) and fluid-electrolyte homeostasis. They are arranged as clusters at the tip of each afferent arteriole. In response to a decrease in BP or extracellular fluid volume, JG cells secrete renin, initiating an enzymatic cascade that culminates in the production of angiotensin II (AngII), a potent vasoconstrictor that restores BP and fluid-electrolyte homeostasis. In turn, AngII exerts negative feedback on renin release concomitantly with increased intracellular Ca
methodsWe generated mice expressing the JG cell-specific genetically encoded Ca
results
conclusionAngII elicits coordinated intracellular and intercellular Ca
Indexed as
blood pressurecalciumjuxtaglomerular apparatusreninrenin-angiotensin system
Identifiers
PMID39763801
PMCPMC11703171
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