Evidence map›Paper›PMID 39763739›Full record

ArticlebioRxiv : the preprint server for biology2025

Novel interactions within the SIR heterochromatin complex potentiate inter-subunit communication and gene repression.

Jenna Kotz, E J Martz, Maya Nelson, Nicole Savoie, Lauren Schmitt, Jordan States, Nathan Holton, Kirk Hansen, Aaron M Johnson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jenna KotzDepartment of Biochemistry and Molecular Genetics.
E J MartzDepartment of Biochemistry and Molecular Genetics.
Maya NelsonDepartment of Biochemistry and Molecular Genetics.
Nicole SavoieDepartment of Biochemistry and Molecular Genetics.
Lauren SchmittDepartment of Biochemistry and Molecular Genetics.
Jordan StatesDepartment of Biochemistry and Molecular Genetics.
Nathan HoltonDepartment of Biochemistry and Molecular Genetics.
Kirk HansenDepartment of Biochemistry and Molecular Genetics.
Aaron M JohnsonDepartment of Biochemistry and Molecular Genetics.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Mechanisms of heterochromatin targeting and epigenetic genome regulationR35GM144358 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Aaron M. Johnson · 2022 to 2026
$2.1M
NCI NIH HHS P30 CA046934NIGMS NIH HHS R35 GM144358
6 · The paper itself

Abstract

Organisms with smaller genomes often perform multiple functions using one multi-subunit protein complex. The

Indexed as

crosslinking-mass spectrometryepigeneticsHDACheterochromatinsirtuinyeast

Identifiers

PMID39763739
PMCPMC11703230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.