Evidence map›Paper›PMID 39763717›Full record

ArticlebioRxiv : the preprint server for biology2025

Mechanistic origins of temperature scaling in the early embryonic cell cycle.

Jan Rombouts, Franco Tavella, Alexandra Vandervelde, Connie Phong, James E Ferrell, Qiong Yang, Lendert Gelens

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jan RomboutsLaboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat, 49, Leuven, Belgium.ORCID 0000-0003-4135-0771
Franco TavellaDepartment of Physics / Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.
Alexandra VanderveldeLaboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat, 49, Leuven, Belgium.
Connie PhongDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.
James E FerrellDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.
Qiong YangDepartment of Physics / Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2442-2094
Lendert GelensLaboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat, 49, Leuven, Belgium.ORCID 0000-0001-7290-9561

Funding

TRAINING & OUTREACH COREP50GM107615 · NIGMS · STANFORD UNIVERSITY · PI FERRELL, JAMES E. · 2013 to 2017
$10.9M
THE ROLE OF MAP KINASE IN THE CELL CYCLER01GM046383 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI FERRELL, JAMES E. · 1991 to 2018
$7.3M
Understanding the robustness of cell cyclesR01GM144584 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Qiong Yang · 2023 to 2026
$1.2M
NIGMS NIH HHS P50 GM107615NIGMS NIH HHS R01 GM046383NIGMS NIH HHS R01 GM144584
6 · The paper itself

Abstract

Temperature profoundly impacts organismal physiology and ecological dynamics, particularly affecting ectothermic species and making them especially vulnerable to climate changes. Although complex physiological processes usually involve dozens of enzymes, empirically it is found that the rates of these processes often obey the Arrhenius equation, which was originally proposed for individual chemical reactions. Here we have examined the temperature scaling of the early embryonic cell cycle, with the goal of understanding why the Arrhenius equation approximately holds and why it breaks down at temperature extremes. Using experimental data from

Indexed as

Cell cycleCell-free extractTemperatureThermal limitsXenopus laevis

Identifiers

PMID39763717
PMCPMC11703202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.