ReviewPeerJ2025
The effect of the Wnt pathway on the osteogenic differentiation of periodontal ligament stem cells in different environments.
Review in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Comparative Effects ofInternational journal of molecular sciences · 2026Article
- FRZB regulates the osteogenic differentiation of periodontal ligament stem cells in an inflammatory microenvironment through Wnt5a-mitochondrial axis.Cell regeneration (London, England) · 2026Article
- Inflammation dynamics modulate periodontal stem cell fate and function.Frontiers in immunology · 2026Review
- Mechanism of CGF in osteogenic differentiation of periodontal ligament stem cells through the Wnt pathway.Organogenesis · 2025Article
- Effects of ECM Components on Periodontal Ligament Stem Cell Differentiation Under Conditions of Disruption of Wnt and TGF-β Signaling Pathways.Journal of functional biomaterials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolar bone defects have always been an urgent problem in the oral cavity. For some patients with periodontal disease or undergoing orthodontic treatment or implant restoration, alveolar bone defects can greatly inconvenience clinical diagnosis and treatment. Periodontal ligament stem cells (PDLSCs) are considered a promising source for stem cell therapy due to their high osteogenic differentiation capability. The osteogenic differentiation of PDLSCs is influenced by various cytokines mediating signaling pathways, as well as a range of biochemical, physical, and chemical factors. Different environments typically impact the Wnt signaling pathway and consequently affect the osteogenic differentiation of PDLSCs. Understanding the effects of the Wnt signaling pathway on the osteogenic differentiation of periodontal ligament stem cells in various environments contributes to addressing the diverse clinical scenarios encountered in the oral environment. This knowledge aids in influencing the pathway through bioengineering or the development of novel materials, thereby enhancing the osteogenic potential of stem cells and providing new diagnostic and therapeutic strategies for clinical practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.