Evidence map›Paper›PMID 39763571›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Judged by your neighbors: A novel framework for personalized assessment of brain structural aging effects in diverse populations.

Ramona Leenings, Nils R Winter, Jan Ernsting, Maximilian Konowski, Vincent Holstein, Susanne Meinert, Jennifer Spanagel, Carlotta Barkhau, Lukas Fisch, Janik Goltermann and 22 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Ramona LeeningsFaculty of Mathematics and Computer Science, University of Münster, Münster, Germany.
Nils R WinterUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.ORCID 0000-0002-6241-1492
Jan ErnstingUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Maximilian KonowskiUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Vincent HolsteinMcLean Hospital, Belmont USA.
Susanne MeinertUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Jennifer SpanagelUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Carlotta BarkhauUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Lukas FischUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Janik GoltermannUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.ORCID 0000-0003-3087-1002
Malte F GerdesUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Dominik GrotegerdUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Elisabeth J LeehrUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Lilian KristInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Stefan N WillichInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Tobias PischonMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID 0000-0003-1568-767X
Henry VölzkeGerman Centre for Cardiovascular Research (DZHK), Greifswald, Germany.
Johannes HauboldInstitute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
Hans-Ulrich KauczorDiagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Thoralf NiendorfBerlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Maike RichterDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Udo DannlowskiUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Xiaoyi JiangFaculty of Mathematics and Computer Science, University of Münster, Münster, Germany.
James ColeDepartment of Computer Science, Centre for Medical Image Computing, University College London, London, United Kingdom.ORCID 0000-0003-1908-5588
Nils OpelDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena Germany.
Tim HahnUniversity of Münster, Institute of Translational Psychiatry, Münster Germany.
NAKO consortium
ADNI consortium
Frontotemporal Lobar Degeneration Neuroimaging Initiative
Australian Imaging Biomarkers and Lifestyle flagship study of ageing

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
The Frontotemporal Lobar Degeneration Neuroimaging InitiativeR01AG032306 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2009 to 2013
$10.0M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASER01AG043434 · NIA · WASHINGTON UNIVERSITY · PI ROE, CATHERINE M · 2012 to 2016
$2.4M
NCATS NIH HHS UL1 TR000448NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS R01 AG032306NIA NIH HHS R01 AG043434NIA NIH HHS U01 AG024904NIBIB NIH HHS R01 EB009352
6 · The paper itself

Abstract

Despite their promise, current neuroimaging biomarkers often fail to capture the full spectrum of inter-individual variability in brain structure and aging effects. This limits their ability to detect subtle norm deviations and impacts their utility for personalized care. We introduce Nearest Neighbor Normativity

Indexed as

Brain AgeDensity-EstimationDiversityNormative ModelingPrecision Medicine

Identifiers

PMID39763571
PMCPMC11703290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.