Evidence map›Paper›PMID 39763532›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Timing of Menarche and Menopause and Epigenetic Aging among U.S. Adults: Results from the National Health and Nutrition Examination Survey 1999-2002.

Saher Daredia, Dennis Khodasevich, Nicole Gladish, Hanyang Shen, Jamaji C Nwanaji-Enwerem, Anne K Bozack, Belinda L Needham, David H Rehkopf, Julianna Deardorff, Andres Cardenas

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Saher DarediaDivision of Epidemiology, School of Public Health, University of California, Berkeley.ORCID 0000-0002-7906-4087
Dennis KhodasevichDepartment of Epidemiology and Population Health, School of Medicine, Stanford University.ORCID 0000-0003-1412-8251
Nicole GladishDepartment of Epidemiology and Population Health, School of Medicine, Stanford University.ORCID 0000-0001-6039-7001
Hanyang ShenDepartment of Epidemiology and Population Health, School of Medicine, Stanford University.ORCID 0000-0003-3273-9777
Jamaji C Nwanaji-EnweremDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0003-0356-4867
Anne K BozackDepartment of Epidemiology and Population Health, School of Medicine, Stanford University.ORCID 0000-0003-0046-5767
Belinda L NeedhamDepartment of Epidemiology, Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan.ORCID 0000-0001-5939-2027
David H RehkopfDepartment of Epidemiology and Population Health, School of Medicine, Stanford University.ORCID 0000-0002-7597-6513
Julianna DeardorffDivision of Community Health Sciences, School of Public Health, University of California, Berkeley.ORCID 0000-0002-4708-5289
Andres CardenasDepartment of Epidemiology and Population Health, School of Medicine, Stanford University.ORCID 0000-0003-2284-3298

Funding

Common and Distinct Influences of Prenatal and Postnatal Early-Life Adversity on Epigenomic Trajectories in Mexican American ChildrenR01MD016595 · NIMHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI Andres Cardenas, Julianna Deardorff · 2022 to 2026
$3.0M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
NIEHS NIH HHS R01 ES031259NIMHD NIH HHS R01 MD016595
6 · The paper itself

Abstract

Reproductive aging, including timing of menarche and menopause, influences long-term morbidity and mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations of age at menarche (N=1,033) and menopause (N=658) with epigenetic aging in a nationally representative sample of women ≥50 years. Later age at menopause was associated with lower GrimAge epigenetic age deviation (

Indexed as

DNA methylationEpigenetic agingMenarcheMenopause

Identifiers

PMID39763532
PMCPMC11702739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.