Evidence map›Paper›PMID 39763518›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception.

Gillian J Bedwell, Luyanduthando Mqadi, Peter Kamerman, Mark R Hutchinson, Romy Parker, Victoria J Madden

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Gillian J BedwellAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4522-5679
Luyanduthando MqadiAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0542-2221
Peter KamermanBrain Function Research group, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-3103-5295
Mark R HutchinsonSchool of Biomedicine, University of Adelaide, South Australia, Australia.ORCID 0000-0003-2154-5950
Romy ParkerAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4823-2487
Victoria J MaddenAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-5357-4062

Funding

Psychosocial distress, inflammatory reactivity and central sensitization in the pathway to HIV-related pain: characterizing the associations and developing a pragmatic, coping-focused intervention.K43TW011442 · FIC · UNIVERSITY OF CAPE TOWN · PI MADDEN, VICTORIA JOY · 2019 to 2023
$674k
FIC NIH HHS K43 TW011442
6 · The paper itself

Abstract

Adversity in childhood elevates the risk of persistent pain in adulthood. Neuroimmune interactions are a candidate mechanistic link between childhood adversity and persistent pain. We aimed to clarify whether immune reactivity is associated with provoked differences in nociceptive processing in adults with a range of childhood adversity. Pain-free adults (n=96; 61 female; median (range) age: 23 (18-65) years old) with a history of mild to severe childhood adversity underwent psychophysical assessments before and after

Identifiers

PMID39763518
PMCPMC11702747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.