ArticleJournal of central nervous system disease2025
Polymorphisms in genes related to inflammation and endothelial function are associated with ischemic stroke and other vascular events in populations at high risk of stroke.
Article in Journal of central nervous system disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interaction between 3-SNP genetic risk score and dietary fats intake on inflammatory markers among overweight and obese women.Journal of diabetes and metabolic disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The association of genetic single-nucleotide polymorphisms (SNPs) related to endothelial function, inflammation, and their outcomes remains poorly studied. Objectives: To evaluate the occurrence of ischemic stroke (IS) and other vascular events, and relationships between 19 SNPs in genes associated with endothelial function and inflammation with outcomes in a population at high risk of stroke. Design: A prospective cohort study and multi-center community-based sectional survey. Methods: As a part of the China National Stroke Screening Survey program, the investigation was carried out in southern China from May 2015 to January 2020. Participants from 8 randomly selected. In people who were determined to be at high risk of stroke, 19 SNPs were examined. Over an average follow-up period of 4.7 years, the results of these subjects were monitored using a longitudinal method. A new IS was the primary outcome assessed, and a combination of new vascular events was the secondary outcome. Results: In total, 2893 participants were classified as high-risk for stroke, and 2698 were monitored for 4.7 years, resulting in 192 participants (7.1%) experiencing various outcomes. Out of these, 118 individuals (4.4%) had a novel IS, 24 (0.9%) suffered a hemorrhagic stroke (HS), 53 (2.0%) developed myocardial infarction (MI), and 33 (1.2%) passed away. Significant variations have been found in the genotype distributions of Conclusion: The incidence of IS and other vascular events was significantly greater among participants who were categorized as being at high risk for stroke. The interacting high-risk genotypes of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.